Antigen-specific NK cell memory in rhesus macaques
View/ Open
Author
Reeves, R. Keith
Li, Hualin
Varner, Valerie
Eslamizar, Leila
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/ni.3227Metadata
Show full item recordCitation
Reeves, R. K., H. Li, S. Jost, E. Blass, H. Li, J. L. Schafer, V. Varner, et al. 2015. “Antigen-specific NK cell memory in rhesus macaques.” Nature immunology 16 (9): 927-932. doi:10.1038/ni.3227. http://dx.doi.org/10.1038/ni.3227.Abstract
Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in murine NK cells. However, it has remained unclear whether this phenomenon also exists in primates. Compared to NK cells from uninfected macaques, we found splenic and hepatic NK cells from SHIV-SF162P3- and SIVmac251-infected animals specifically lysed Gag- and Env-pulsed dendritic cells (DCs) in an NKG2-dependent fashion. Moreover, splenic and hepatic NK cells from Ad26-vaccinated macaques efficiently lysed antigen-matched but not antigen-mismatched targets 5 years post-vaccination. These data demonstrate that robust, durable, antigen-specific NK cell memory can be induced in primates following both infection and vaccination, and could be important for vaccines against HIV-1 and other pathogens.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545390/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318708
Collections
- FAS Scholarly Articles [18256]
- HMS Scholarly Articles [17917]
Contact administrator regarding this item (to report mistakes or request changes)