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dc.contributor.authorLarsen, Sofus C.en_US
dc.contributor.authorÄngquist, Larsen_US
dc.contributor.authorLaurin, Charlesen_US
dc.contributor.authorMorgen, Camilla S.en_US
dc.contributor.authorJakobsen, Marianne U.en_US
dc.contributor.authorPaternoster, Laviniaen_US
dc.contributor.authorSmith, George Daveyen_US
dc.contributor.authorOlsen, Sjurdur F.en_US
dc.contributor.authorSørensen, Thorkild I. A.en_US
dc.contributor.authorNohr, Ellen A.en_US
dc.date.accessioned2016-04-01T15:48:49Z
dc.date.issued2016en_US
dc.identifier.citationLarsen, Sofus C., Lars Ängquist, Charles Laurin, Camilla S. Morgen, Marianne U. Jakobsen, Lavinia Paternoster, George Davey Smith, Sjurdur F. Olsen, Thorkild I. A. Sørensen, and Ellen A. Nohr. 2016. “Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity.” PLoS ONE 11 (3): e0150105. doi:10.1371/journal.pone.0150105. http://dx.doi.org/10.1371/journal.pone.0150105.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318722
dc.description.abstractBackground: Studies suggest that fish consumption can restrict weight gain. However, little is known about how fish consumption affects gestational weight gain (GWG), and whether this relationship depends on genetic makeup. Objective: To examine the association between fish consumption and GWG, and whether this relationship is dependent on molecular genetic predisposition to obesity. Design: A nested case-cohort study based on the Danish National Birth Cohort (DNBC) sampling the most obese women (n = 990) and a random sample of the remaining participants (n = 1,128). Replication of statistically significant findings was attempted in the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 4,841). We included 32 body mass index (BMI) associated single nucleotide polymorphisms (SNPs) and 5 SNPs found associated with GWG. BMI associated SNPs were combined in a genetic risk score (GRS). Associations between consumption of fish, GRS or individual variants and GWG were analysed, and interactions between fish and the GRS or individual variants were examined. Results: In the DNBC, each portion/week (150 g) of fatty fish was associated with a higher GWG of 0.58 kg (95% CI: 0.16, 0.99, P<0.01). For total fish and lean fish, similar patterns were observed, but these associations were not statistically significant. We found no association between GRS and GWG, and no interactions between GRS and dietary fish on GWG. However, we found an interaction between the PPARG Pro12Ala variant and dietary fish. Each additional Pro12Ala G-allele was associated with a GWG of -0.83 kg (95% CI: -1.29, -0.37, P<0.01) per portion/week of dietary fish, with the same pattern for both lean and fatty fish. In ALSPAC, we were unable to replicate these findings. Conclusion: We found no consistent evidence of association between fish consumption and GWG, and our results indicate that the association between dietary fish and GWG has little or no dependency on GRS or individual SNPs.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0150105en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773113/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectPhysiologyen
dc.subjectPhysiological Parametersen
dc.subjectBody Weighten
dc.subjectObesityen
dc.subjectMedicine and Health Sciencesen
dc.subjectBody Mass Indexen
dc.subjectWomen's Healthen
dc.subjectMaternal Healthen
dc.subjectPregnancyen
dc.subjectObstetrics and Gynecologyen
dc.subjectWeight Gainen
dc.subjectGeneticsen
dc.subjectHuman Geneticsen
dc.subjectNutritionen
dc.subjectDieten
dc.subjectAlcohol Consumptionen
dc.subjectGenetics of Diseaseen
dc.subjectGenetic Predispositionen
dc.subjectBiochemistryen
dc.subjectLipidsen
dc.subjectFatty Acidsen
dc.titleAssociation between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesityen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorOlsen, Sjurdur F.en_US
dc.date.available2016-04-01T15:48:49Z
dc.identifier.doi10.1371/journal.pone.0150105*
dash.contributor.affiliatedOlsen, Sjurdur


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