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dc.contributor.authorde Oliveira Otto, Marcia C.en_US
dc.contributor.authorAfshin, Ashkanen_US
dc.contributor.authorMicha, Renataen_US
dc.contributor.authorKhatibzadeh, Shahaben_US
dc.contributor.authorFahimi, Samanen_US
dc.contributor.authorSingh, Gitanjalien_US
dc.contributor.authorDanaei, Goodarzen_US
dc.contributor.authorSichieri, Roselyen_US
dc.contributor.authorMonteiro, Carlos Aen_US
dc.contributor.authorLouzada, Maria L. C.en_US
dc.contributor.authorEzzati, Majiden_US
dc.contributor.authorMozaffarian, Dariushen_US
dc.date.accessioned2016-04-01T15:48:54Z
dc.date.issued2016en_US
dc.identifier.citationde Oliveira Otto, M. C., A. Afshin, R. Micha, S. Khatibzadeh, S. Fahimi, G. Singh, G. Danaei, et al. 2016. “The Impact of Dietary and Metabolic Risk Factors on Cardiovascular Diseases and Type 2 Diabetes Mortality in Brazil.” PLoS ONE 11 (3): e0151503. doi:10.1371/journal.pone.0151503. http://dx.doi.org/10.1371/journal.pone.0151503.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318734
dc.description.abstractBackground: Trends in food availability and metabolic risk factors in Brazil suggest a shift toward unhealthy dietary patterns and increased cardiometabolic disease risk, yet little is known about the impact of dietary and metabolic risk factors on cardiometabolic mortality in Brazil. Methods: Based on data from Global Burden of Disease (GBD) Study, we used comparative risk assessment to estimate the burden of 11 dietary and 4 metabolic risk factors on mortality due to cardiovascular diseases and diabetes in Brazil in 2010. Information on national diets and metabolic risks were obtained from the Brazilian Household Budget Survey, the Food and Agriculture Organization database, and large observational studies including Brazilian adults. Relative risks for each risk factor were obtained from meta-analyses of randomized trials or prospective cohort studies; and disease-specific mortality from the GBD 2010 database. We quantified uncertainty using probabilistic simulation analyses, incorporating uncertainty in dietary and metabolic data and relative risks by age and sex. Robustness of findings was evaluated by sensitivity to varying feasible optimal levels of each risk factor. Results: In 2010, high systolic blood pressure (SBP) and suboptimal diet were the largest contributors to cardiometabolic deaths in Brazil, responsible for 214,263 deaths (95% uncertainty interval [UI]: 195,073 to 233,936) and 202,949 deaths (95% UI: 194,322 to 211,747), respectively. Among individual dietary factors, low intakes of fruits and whole grains and high intakes of sodium were the largest contributors to cardiometabolic deaths. For premature cardiometabolic deaths (before age 70 years, representing 40% of cardiometabolic deaths), the leading risk factors were suboptimal diet (104,169 deaths; 95% UI: 99,964 to 108,002), high SBP (98,923 deaths; 95%UI: 92,912 to 104,609) and high body-mass index (BMI) (42,643 deaths; 95%UI: 40,161 to 45,111). Conclusion: suboptimal diet, high SBP, and high BMI are major causes of cardiometabolic death in Brazil, informing priorities for policy initiatives.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0151503en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798497/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectCardiovascular Medicineen
dc.subjectCardiovascular Diseasesen
dc.subjectHealth Careen
dc.subjectHealth Risk Analysisen
dc.subjectEndocrinologyen
dc.subjectEndocrine Disordersen
dc.subjectDiabetes Mellitusen
dc.subjectMetabolic Disordersen
dc.subjectNeurologyen
dc.subjectCerebrovascular Diseasesen
dc.subjectStrokeen
dc.subjectIschemic Strokeen
dc.subjectVascular Medicineen
dc.subjectPeople and Placesen
dc.subjectPopulation Groupingsen
dc.subjectAge Groupsen
dc.subjectAdultsen
dc.subjectBiology and Life Sciencesen
dc.subjectBiochemistryen
dc.subjectMetabolismen
dc.subjectCarbohydrate Metabolismen
dc.subjectGlucose Metabolismen
dc.subjectHemorrhagic Strokeen
dc.subjectAgricultureen
dc.subjectAnimal Productsen
dc.subjectMeaten
dc.subjectNutritionen
dc.subjectDieten
dc.subjectFooden
dc.titleThe Impact of Dietary and Metabolic Risk Factors on Cardiovascular Diseases and Type 2 Diabetes Mortality in Brazilen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorDanaei, Goodarzen_US
dc.date.available2016-04-01T15:48:54Z
dc.identifier.doi10.1371/journal.pone.0151503*
dash.authorsorderedfalse
dash.contributor.affiliatedDanaei, Goodarz


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