Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
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Author
Berndt, Sonja I.
Camp, Nicola J.
Skibola, Christine F.
Vijai, Joseph
Wang, Zhaoming
Gu, Jian
Nieters, Alexandra
Smedby, Karin E.
Monnereau, Alain
Cozen, Wendy
Cox, Angela
Wang, Sophia S.
Lan, Qing
Teras, Lauren R.
Machado, Moara
Yeager, Meredith
Brooks-Wilson, Angela R.
Hartge, Patricia
Purdue, Mark P.
Vajdic, Claire M.
Cocco, Pierluigi
Zhang, Yawei
Giles, Graham G.
Zeleniuch-Jacquotte, Anne
Lawrence, Charles
Montalvan, Rebecca
Burdett, Laurie
Hutchinson, Amy
Ye, Yuanqing
Call, Timothy G.
Shanafelt, Tait D.
Novak, Anne J.
Kay, Neil E.
Liebow, Mark
Cunningham, Julie M.
Allmer, Cristine
Hjalgrim, Henrik
Melbye, Mads
Glimelius, Bengt
Chang, Ellen T.
Glenn, Martha
Curtin, Karen
Cannon-Albright, Lisa A.
Diver, W Ryan
Link, Brian K.
Weiner, George J.
Conde, Lucia
Bracci, Paige M.
Riby, Jacques
Arnett, Donna K.
Zhi, Degui
Leach, Justin M.
Holly, Elizabeth A.
Jackson, Rebecca D.
Tinker, Lesley F.
Benavente, Yolanda
Sala, Núria
Casabonne, Delphine
Becker, Nikolaus
Boffetta, Paolo
Brennan, Paul
Foretova, Lenka
Maynadie, Marc
McKay, James
Staines, Anthony
Chaffee, Kari G.
Achenbach, Sara J.
Vachon, Celine M.
Goldin, Lynn R.
Strom, Sara S.
Leis, Jose F.
Weinberg, J. Brice
Caporaso, Neil E.
Norman, Aaron D.
De Roos, Anneclaire J.
Morton, Lindsay M.
Severson, Richard K.
Riboli, Elio
Vineis, Paolo
Kaaks, Rudolph
Masala, Giovanna
Weiderpass, Elisabete
Chirlaque, María- Dolores
Vermeulen, Roel C. H.
Travis, Ruth C.
Southey, Melissa C.
Milne, Roger L.
Albanes, Demetrius
Virtamo, Jarmo
Weinstein, Stephanie
Clavel, Jacqueline
Zheng, Tongzhang
Holford, Theodore R.
Villano, Danylo J.
Maria, Ann
Spinelli, John J.
Gascoyne, Randy D.
Connors, Joseph M.
Kricker, Anne
Turner, Jenny
Ennas, Maria Grazia
Ferri, Giovanni M.
Miligi, Lucia
Ma, Baoshan
Huang, Jinyan
Crouch, Simon
Park, Ju-Hyun
Chatterjee, Nilanjan
North, Kari E.
Snowden, John A.
Wright, Josh
Fraumeni, Joseph F.
Offit, Kenneth
Wu, Xifeng
de Sanjose, Silvia
Cerhan, James R.
Chanock, Stephen J.
Rothman, Nathaniel
Slager, Susan L.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ncomms10933Metadata
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Berndt, S. I., N. J. Camp, C. F. Skibola, J. Vijai, Z. Wang, J. Gu, A. Nieters, et al. 2016. “Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.” Nature Communications 7 (1): 10933. doi:10.1038/ncomms10933. http://dx.doi.org/10.1038/ncomms10933.Abstract
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10−11), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10−8) and 3q28 (rs9815073, LPP, P=3.62 × 10−8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10−11) in the combined analysis. We find suggestive evidence (P<5 × 10−7) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10−8) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10−7). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786871/pdf/Terms of Use
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