dc.contributor.author | Berndt, Sonja I. | en_US |
dc.contributor.author | Camp, Nicola J. | en_US |
dc.contributor.author | Skibola, Christine F. | en_US |
dc.contributor.author | Vijai, Joseph | en_US |
dc.contributor.author | Wang, Zhaoming | en_US |
dc.contributor.author | Gu, Jian | en_US |
dc.contributor.author | Nieters, Alexandra | en_US |
dc.contributor.author | Kelly, Rachel S. | en_US |
dc.contributor.author | Smedby, Karin E. | en_US |
dc.contributor.author | Monnereau, Alain | en_US |
dc.contributor.author | Cozen, Wendy | en_US |
dc.contributor.author | Cox, Angela | en_US |
dc.contributor.author | Wang, Sophia S. | en_US |
dc.contributor.author | Lan, Qing | en_US |
dc.contributor.author | Teras, Lauren R. | en_US |
dc.contributor.author | Machado, Moara | en_US |
dc.contributor.author | Yeager, Meredith | en_US |
dc.contributor.author | Brooks-Wilson, Angela R. | en_US |
dc.contributor.author | Hartge, Patricia | en_US |
dc.contributor.author | Purdue, Mark P. | en_US |
dc.contributor.author | Birmann, Brenda M. | en_US |
dc.contributor.author | Vajdic, Claire M. | en_US |
dc.contributor.author | Cocco, Pierluigi | en_US |
dc.contributor.author | Zhang, Yawei | en_US |
dc.contributor.author | Giles, Graham G. | en_US |
dc.contributor.author | Zeleniuch-Jacquotte, Anne | en_US |
dc.contributor.author | Lawrence, Charles | en_US |
dc.contributor.author | Montalvan, Rebecca | en_US |
dc.contributor.author | Burdett, Laurie | en_US |
dc.contributor.author | Hutchinson, Amy | en_US |
dc.contributor.author | Ye, Yuanqing | en_US |
dc.contributor.author | Call, Timothy G. | en_US |
dc.contributor.author | Shanafelt, Tait D. | en_US |
dc.contributor.author | Novak, Anne J. | en_US |
dc.contributor.author | Kay, Neil E. | en_US |
dc.contributor.author | Liebow, Mark | en_US |
dc.contributor.author | Cunningham, Julie M. | en_US |
dc.contributor.author | Allmer, Cristine | en_US |
dc.contributor.author | Hjalgrim, Henrik | en_US |
dc.contributor.author | Adami, Hans-Olov | en_US |
dc.contributor.author | Melbye, Mads | en_US |
dc.contributor.author | Glimelius, Bengt | en_US |
dc.contributor.author | Chang, Ellen T. | en_US |
dc.contributor.author | Glenn, Martha | en_US |
dc.contributor.author | Curtin, Karen | en_US |
dc.contributor.author | Cannon-Albright, Lisa A. | en_US |
dc.contributor.author | Diver, W Ryan | en_US |
dc.contributor.author | Link, Brian K. | en_US |
dc.contributor.author | Weiner, George J. | en_US |
dc.contributor.author | Conde, Lucia | en_US |
dc.contributor.author | Bracci, Paige M. | en_US |
dc.contributor.author | Riby, Jacques | en_US |
dc.contributor.author | Arnett, Donna K. | en_US |
dc.contributor.author | Zhi, Degui | en_US |
dc.contributor.author | Leach, Justin M. | en_US |
dc.contributor.author | Holly, Elizabeth A. | en_US |
dc.contributor.author | Jackson, Rebecca D. | en_US |
dc.contributor.author | Tinker, Lesley F. | en_US |
dc.contributor.author | Benavente, Yolanda | en_US |
dc.contributor.author | Sala, Núria | en_US |
dc.contributor.author | Casabonne, Delphine | en_US |
dc.contributor.author | Becker, Nikolaus | en_US |
dc.contributor.author | Boffetta, Paolo | en_US |
dc.contributor.author | Brennan, Paul | en_US |
dc.contributor.author | Foretova, Lenka | en_US |
dc.contributor.author | Maynadie, Marc | en_US |
dc.contributor.author | McKay, James | en_US |
dc.contributor.author | Staines, Anthony | en_US |
dc.contributor.author | Chaffee, Kari G. | en_US |
dc.contributor.author | Achenbach, Sara J. | en_US |
dc.contributor.author | Vachon, Celine M. | en_US |
dc.contributor.author | Goldin, Lynn R. | en_US |
dc.contributor.author | Strom, Sara S. | en_US |
dc.contributor.author | Leis, Jose F. | en_US |
dc.contributor.author | Weinberg, J. Brice | en_US |
dc.contributor.author | Caporaso, Neil E. | en_US |
dc.contributor.author | Norman, Aaron D. | en_US |
dc.contributor.author | De Roos, Anneclaire J. | en_US |
dc.contributor.author | Morton, Lindsay M. | en_US |
dc.contributor.author | Severson, Richard K. | en_US |
dc.contributor.author | Riboli, Elio | en_US |
dc.contributor.author | Vineis, Paolo | en_US |
dc.contributor.author | Kaaks, Rudolph | en_US |
dc.contributor.author | Masala, Giovanna | en_US |
dc.contributor.author | Weiderpass, Elisabete | en_US |
dc.contributor.author | Chirlaque, María- Dolores | en_US |
dc.contributor.author | Vermeulen, Roel C. H. | en_US |
dc.contributor.author | Travis, Ruth C. | en_US |
dc.contributor.author | Southey, Melissa C. | en_US |
dc.contributor.author | Milne, Roger L. | en_US |
dc.contributor.author | Albanes, Demetrius | en_US |
dc.contributor.author | Virtamo, Jarmo | en_US |
dc.contributor.author | Weinstein, Stephanie | en_US |
dc.contributor.author | Clavel, Jacqueline | en_US |
dc.contributor.author | Zheng, Tongzhang | en_US |
dc.contributor.author | Holford, Theodore R. | en_US |
dc.contributor.author | Villano, Danylo J. | en_US |
dc.contributor.author | Maria, Ann | en_US |
dc.contributor.author | Spinelli, John J. | en_US |
dc.contributor.author | Gascoyne, Randy D. | en_US |
dc.contributor.author | Connors, Joseph M. | en_US |
dc.contributor.author | Bertrand, Kimberly A. | en_US |
dc.contributor.author | Giovannucci, Edward | en_US |
dc.contributor.author | Kraft, Peter | en_US |
dc.contributor.author | Kricker, Anne | en_US |
dc.contributor.author | Turner, Jenny | en_US |
dc.contributor.author | Ennas, Maria Grazia | en_US |
dc.contributor.author | Ferri, Giovanni M. | en_US |
dc.contributor.author | Miligi, Lucia | en_US |
dc.contributor.author | Liang, Liming | en_US |
dc.contributor.author | Ma, Baoshan | en_US |
dc.contributor.author | Huang, Jinyan | en_US |
dc.contributor.author | Crouch, Simon | en_US |
dc.contributor.author | Park, Ju-Hyun | en_US |
dc.contributor.author | Chatterjee, Nilanjan | en_US |
dc.contributor.author | North, Kari E. | en_US |
dc.contributor.author | Snowden, John A. | en_US |
dc.contributor.author | Wright, Josh | en_US |
dc.contributor.author | Fraumeni, Joseph F. | en_US |
dc.contributor.author | Offit, Kenneth | en_US |
dc.contributor.author | Wu, Xifeng | en_US |
dc.contributor.author | de Sanjose, Silvia | en_US |
dc.contributor.author | Cerhan, James R. | en_US |
dc.contributor.author | Chanock, Stephen J. | en_US |
dc.contributor.author | Rothman, Nathaniel | en_US |
dc.contributor.author | Slager, Susan L. | en_US |
dc.date.accessioned | 2016-04-01T15:50:00Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Berndt, S. I., N. J. Camp, C. F. Skibola, J. Vijai, Z. Wang, J. Gu, A. Nieters, et al. 2016. “Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.” Nature Communications 7 (1): 10933. doi:10.1038/ncomms10933. http://dx.doi.org/10.1038/ncomms10933. | en |
dc.identifier.issn | 2041-1723 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318780 | |
dc.description.abstract | Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10−11), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10−8) and 3q28 (rs9815073, LPP, P=3.62 × 10−8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10−11) in the combined analysis. We find suggestive evidence (P<5 × 10−7) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10−8) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10−7). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. | en |
dc.language.iso | en_US | en |
dc.publisher | Nature Publishing Group | en |
dc.relation.isversionof | doi:10.1038/ncomms10933 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786871/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature Communications | en |
dash.depositing.author | Kelly, Rachel S. | en_US |
dc.date.available | 2016-04-01T15:50:00Z | |
dc.identifier.doi | 10.1038/ncomms10933 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Birmann, Brenda | |
dash.contributor.affiliated | Kelly, Rachel | |
dash.contributor.affiliated | Adami, Hans-Olov | |
dash.contributor.affiliated | Bertrand, Kimberly | |
dash.contributor.affiliated | Liang, Liming | |
dash.contributor.affiliated | Giovannucci, Edward | |
dash.contributor.affiliated | Kraft, Phillip | |