Immunohaematological reference values for HIV-negative healthy adults in Botswana

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Immunohaematological reference values for HIV-negative healthy adults in Botswana

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Title: Immunohaematological reference values for HIV-negative healthy adults in Botswana
Author: Mine, Madisa; Moyo, Sikhulile; Stevens, Penny; Michael, Kurt; Novitsky, Vladimir A.; Makhaola, Kgomotso; Asmelash, Aida; Molefhabangwe, S’khatele; Woldegabriel, Elias; Mothowaeng, Gaseboloke; Maruta, Talkmore; Kamhukamwe, Charity; Mangwendeza, Phibeon M.; Holmes-Pretorius, Molly; Mtoni, Isaac; Motswaledi, Modisa; Musonda, Rosemary Mubanga; Ndwapi, Ndwapi; Makhema, Joseph Moeketsi; Marlink, Richard G.; Seipone, Khumo; Gaolathe, Tendani; Essex, Myron Elmer

Note: Order does not necessarily reflect citation order of authors.

Citation: Mine, Madisa, Sikhulile Moyo, Penny Stevens, Kurt Michael, Vladimir Novitsky, Kgomotso Makhaola, Aida Asmelash, et al. 2011. “Immunohaematological Reference Values for HIV-Negative Healthy Adults in Botswana.” African Journal of Laboratory Medicine 1 (1) (December 13). doi:10.4102/ajlm.v1i1.5.
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Abstract: BACKGROUND: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers' kits and textbooks. OBJECTIVES: The aim of this study was to determine the means, medians, 2.5th and 97.5th percentile reference intervals, for normal immunohaematological values in healthy adults in Botswana. METHOD: A total of 261 healthy participants comprising 126 men (48%) and 135 (52%) women were enrolled in the southern part of Botswana, and immunological and haematological laboratory parameters were measured. RESULTS: The mean age was 28.8 (95% Confidence Interval [CI] 27.7-29.8) years, with a median of 27 years and a range 18-66 years. The mean haemoglobin level was significantly lower for women (12.4 g/dL; 95% CI 12.1% - 12.7%) than men (15.1 g/dL; 95% CI 14.9% - 15.3%). The women's haemoglobin reference values (9.0 g/dL - 15.0 g/dL) levels were lower than observed in predominantly White populations (12.0 g/dL - 16.0 g/dL), but comparable with regional consensus reference intervals (9.5 g/dL - 15.8 g/dL) recently defined for East and Southern Africa. CONCLUSION: The established values provide an important tool for patient management and could influence decisions on inclusion of participants and adverse events in clinical trials conducted locally.
Published Version: doi:10.4102/ajlm.v1i1.5
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