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dc.contributor.authorKostic, Aleksandar David
dc.contributor.authorGevers, D.
dc.contributor.authorPedamallu, Chandra Sekhar
dc.contributor.authorMichaud, Monia
dc.contributor.authorDuke, F.
dc.contributor.authorEarl, A. M.
dc.contributor.authorOjesina, Akinyemi Ifedapo
dc.contributor.authorJung, J.
dc.contributor.authorBass, Adam Joel
dc.contributor.authorTabernero, J.
dc.contributor.authorBaselga, J.
dc.contributor.authorLiu, C.
dc.contributor.authorShivdasani, Ramesh Arjun
dc.contributor.authorOgino, Shuji
dc.contributor.authorBirren, B. W.
dc.contributor.authorHuttenhower, Curtis
dc.contributor.authorGarrett, Wendy S.
dc.contributor.authorMeyerson, Matthew Langer
dc.date.accessioned2016-04-26T17:52:25Z
dc.date.issued2011
dc.identifier.citationKostic, A. D., D. Gevers, C. S. Pedamallu, M. Michaud, F. Duke, A. M. Earl, A. I. Ojesina, et al. 2011. “Genomic Analysis Identifies Association of Fusobacterium with Colorectal Carcinoma.” Genome Research 22 (2) (October 18): 292–298. doi:10.1101/gr.126573.111.en_US
dc.identifier.issn1088-9051en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26835866
dc.description.abstractThe tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to carcinogenesis; however, the role of the microbiota is the least well understood. We have characterized the composition of the microbiota in colorectal carcinoma using whole genome sequences from nine tumor/normal pairs. Fusobacterium sequences were enriched in carcinomas, confirmed by quantitative PCR and 16S rDNA sequence analysis of 95 carcinoma/normal DNA pairs, while the Bacteroidetes and Firmicutes phyla were depleted in tumors. Fusobacteria were also visualized within colorectal tumors using FISH. These findings reveal alterations in the colorectal cancer microbiota; however, the precise role of Fusobacteria in colorectal carcinoma pathogenesis requires further investigation.en_US
dc.language.isoen_USen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.relation.isversionofdoi:10.1101/gr.126573.111en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266036/en_US
dash.licenseLAA
dc.titleGenomic analysis identifies association of Fusobacterium with colorectal carcinomaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalGenome Researchen_US
dash.depositing.authorGarrett, Wendy S.
dc.date.available2016-04-26T17:52:25Z
dc.identifier.doi10.1101/gr.126573.111*
dash.authorsorderedfalse
dash.contributor.affiliatedMichaud, Monia
dash.contributor.affiliatedKostic, Aleksandar
dash.contributor.affiliatedPedamallu, Chandra Sekhar
dash.contributor.affiliatedOjesina, Akinyemi Ifedapo
dash.contributor.affiliatedGarrett, Wendy
dash.contributor.affiliatedMeyerson, Matthew
dash.contributor.affiliatedOgino, Shuji
dash.contributor.affiliatedShivdasani, Ramesh
dash.contributor.affiliatedBass, Adam
dash.contributor.affiliatedHuttenhower, Curtis


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