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dc.contributor.authorHanschen, Erik R.en_US
dc.contributor.authorMarriage, Tara N.en_US
dc.contributor.authorFerris, Patrick J.en_US
dc.contributor.authorHamaji, Takashien_US
dc.contributor.authorToyoda, Atsushien_US
dc.contributor.authorFujiyama, Asaoen_US
dc.contributor.authorNeme, Rafiken_US
dc.contributor.authorNoguchi, Hidekien_US
dc.contributor.authorMinakuchi, Yoheien_US
dc.contributor.authorSuzuki, Masahiroen_US
dc.contributor.authorKawai-Toyooka, Hirokoen_US
dc.contributor.authorSmith, David R.en_US
dc.contributor.authorSparks, Halleen_US
dc.contributor.authorAnderson, Jadenen_US
dc.contributor.authorBakarić, Roberten_US
dc.contributor.authorLuria, Victoren_US
dc.contributor.authorKarger, Amiren_US
dc.contributor.authorKirschner, Marc W.en_US
dc.contributor.authorDurand, Pierre M.en_US
dc.contributor.authorMichod, Richard E.en_US
dc.contributor.authorNozaki, Hisayoshien_US
dc.contributor.authorOlson, Bradley J. S. C.en_US
dc.date.accessioned2016-05-02T16:59:08Z
dc.date.issued2016en_US
dc.identifier.citationHanschen, E. R., T. N. Marriage, P. J. Ferris, T. Hamaji, A. Toyoda, A. Fujiyama, R. Neme, et al. 2016. “The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity.” Nature Communications 7 (1): 11370. doi:10.1038/ncomms11370. http://dx.doi.org/10.1038/ncomms11370.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26859928
dc.description.abstractThe transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. The volvocine green algae are a tractable system for understanding the genetic basis of multicellularity including the initial formation of cooperative cell groups. Here we report the genome sequence of the undifferentiated colonial alga, Gonium pectorale, where group formation evolved by co-option of the retinoblastoma cell cycle regulatory pathway. Significantly, expression of the Gonium retinoblastoma cell cycle regulator in unicellular Chlamydomonas causes it to become colonial. The presence of these changes in undifferentiated Gonium indicates extensive group-level adaptation during the initial step in the evolution of multicellularity. These results emphasize an early and formative step in the evolution of multicellularity, the evolution of cell cycle regulation, one that may shed light on the evolutionary history of other multicellular innovations and evolutionary transitions.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/ncomms11370en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844696/pdf/en
dash.licenseLAAen_US
dc.titleThe Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularityen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorLuria, Victoren_US
dc.date.available2016-05-02T16:59:08Z
dc.identifier.doi10.1038/ncomms11370*
dash.authorsorderedfalse
dash.contributor.affiliatedKarger, Amir
dash.contributor.affiliatedLuria, Victor
dash.contributor.affiliatedKirschner, Marc


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