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dc.contributor.authorRamanan, Vijay Ken_US
dc.contributor.authorNho, Kwangsiken_US
dc.contributor.authorShen, Lien_US
dc.contributor.authorRisacher, Shannon L.en_US
dc.contributor.authorKim, Sungeunen_US
dc.contributor.authorMcDonald, Brenna C.en_US
dc.contributor.authorFarlow, Martin R.en_US
dc.contributor.authorForoud, Tatiana M.en_US
dc.contributor.authorGao, Sujuanen_US
dc.contributor.authorSoininen, Hilkkaen_US
dc.contributor.authorKłoszewska, Iwonaen_US
dc.contributor.authorMecocci, Patriziaen_US
dc.contributor.authorTsolaki, Magdaen_US
dc.contributor.authorVellas, Brunoen_US
dc.contributor.authorLovestone, Simonen_US
dc.contributor.authorAisen, Paul S.en_US
dc.contributor.authorPetersen, Ronald C.en_US
dc.contributor.authorJack, Clifford R.en_US
dc.contributor.authorShaw, Leslie M.en_US
dc.contributor.authorTrojanowski, John Q.en_US
dc.contributor.authorWeiner, Michael W.en_US
dc.contributor.authorGreen, Robert C.en_US
dc.contributor.authorToga, Arthur W.en_US
dc.contributor.authorDe Jager, Philip L.en_US
dc.contributor.authorYu, Leien_US
dc.contributor.authorBennett, David A.en_US
dc.contributor.authorSaykin, Andrew J.en_US
dc.date.accessioned2016-05-02T16:59:30Z
dc.date.issued2014en_US
dc.identifier.citationRamanan, V. K., K. Nho, L. Shen, S. L. Risacher, S. Kim, B. C. McDonald, M. R. Farlow, et al. 2014. “FASTKD2 is associated with memory and hippocampal structure in older adults.” Molecular psychiatry 20 (10): 1197-1204. doi:10.1038/mp.2014.142. http://dx.doi.org/10.1038/mp.2014.142.en
dc.identifier.issn1359-4184en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26860022
dc.description.abstractMemory impairment is the cardinal early feature of Alzheimer's disease (AD), a highly prevalent disorder whose causes remain only partially understood. To identify novel genetic predictors, we used an integrative genomics approach to perform the largest study to date of human memory (n=14,781). Using a genome-wide screen, we discovered a novel association of a polymorphism in the pro-apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2; rs7594645-G) with better memory performance and replicated this finding in independent samples. Consistent with a neuroprotective effect, rs7594645-G carriers exhibited increased hippocampal volume and gray matter density and decreased cerebrospinal fluid levels of apoptotic mediators. The MTOR (mechanistic target of rapamycin) gene and pathways related to endocytosis, cholinergic neurotransmission, EGFR signaling, and immune regulation, among others, also displayed association with memory. These findings nominate FASTKD2 as a target for modulating neurodegeneration and suggest potential mechanisms for therapies to combat memory loss in normal cognitive aging and dementia.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/mp.2014.142en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427556/pdf/en
dash.licenseLAAen_US
dc.subjectgenome-wide association study (GWAS)en
dc.subjectAlzheimer's disease (AD)en
dc.subjectdementiaen
dc.subjectcognitive agingen
dc.subjectmemoryen
dc.subjectmagnetic resonance imaging (MRI)en
dc.subjectapoptosisen
dc.subjectneurodegenerationen
dc.titleFASTKD2 is associated with memory and hippocampal structure in older adultsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalMolecular psychiatryen
dash.depositing.authorGreen, Robert C.en_US
dc.date.available2016-05-02T16:59:30Z
dc.identifier.doi10.1038/mp.2014.142*
dash.authorsorderedfalse
dash.contributor.affiliatedDe Jager, Philip
dash.contributor.affiliatedGreen, Robert


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