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dc.contributor.authorXu, Xiaoyangen_US
dc.contributor.authorHo, Williamen_US
dc.contributor.authorZhang, Xueqingen_US
dc.contributor.authorBertrand, Nicolasen_US
dc.contributor.authorFarokhzad, Omiden_US
dc.date.accessioned2016-05-02T16:59:34Z
dc.date.issued2015en_US
dc.identifier.citationXu, Xiaoyang, William Ho, Xueqing Zhang, Nicolas Bertrand, and Omid Farokhzad. 2015. “Cancer Nanomedicine: From Targeted Delivery to Combination Therapy.” Trends in molecular medicine 21 (4): 223-232. doi:10.1016/j.molmed.2015.01.001. http://dx.doi.org/10.1016/j.molmed.2015.01.001.en
dc.identifier.issn1471-4914en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26860036
dc.description.abstractThe advent of nanomedicine marks an unparalleled opportunity to advance the treatment of a variety of diseases, including cancer. The unique properties of nanoparticles, such as large surface-to volume ratio, small size, the ability to encapsulate a variety of drugs, and tunable surface chemistry, gives them many advantages over their bulk counterparts. This includes multivalent surface modification with targeting ligands, efficient navigation of the complex in vivo environment, increased intracellular trafficking, and sustained release of drug payload. These advantages make nanoparticles a mode of treatment potentially superior to conventional cancer therapies. This article highlights the most recent developments in cancer treatment using nanoparticles as drug-delivery vehicles, including promising opportunities in targeted and combination therapy.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1016/j.molmed.2015.01.001en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385479/pdf/en
dash.licenseLAAen_US
dc.subjectNanomedicineen
dc.subjectTargeted Deliveryen
dc.subjectCombination Therapyen
dc.subjectCanceren
dc.titleCancer Nanomedicine: From Targeted Delivery to Combination Therapyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalTrends in molecular medicineen
dash.depositing.authorFarokhzad, Omiden_US
dc.date.available2016-05-02T16:59:34Z
dc.identifier.doi10.1016/j.molmed.2015.01.001*
dash.contributor.affiliatedFarokhzad, Omid


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