Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma

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Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma

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Title: Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma
Author: Marmarelis, Melina E.; Davis, Meredith R.; Sethi, Nilay S.; Krajewksi, Katherine M.; McKay, Rana R.; Choueiri, Toni K.; Ott, Patrick A.

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Citation: Marmarelis, Melina E., Meredith R. Davis, Nilay S. Sethi, Katherine M. Krajewksi, Rana R. McKay, Toni K. Choueiri, and Patrick A. Ott. 2016. “Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma.” Journal for Immunotherapy of Cancer 4 (1): 26. doi:10.1186/s40425-016-0129-x. http://dx.doi.org/10.1186/s40425-016-0129-x.
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Abstract: Blockade of the immunological checkpoint programmed death 1 (PD-1) using monoclonal antibodies has shown robust anti-tumor activity across a broad range of solid and hematological malignancies including melanoma and renal cell carcinoma (RCC). Characteristic markers such as the presence of tumor infiltrating lymphocytes, PD-L1 status, and mutational load may be equally or even more important in predicting clinical benefit from PD-1 pathway blockade than tumor histology. This case of a patient with concurrent metastatic melanoma and metastatic RCC, both of which were controlled for more than a year after a single dose of the anti-PD-1 antibody pembrolizumab, illustrates the potential to simultaneously treat distinct immunogenic tumors with anti-PD-1 agents.
Published Version: doi:10.1186/s40425-016-0129-x
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837591/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:26860040
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