Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation

View/ Open
Author
Ono, Wanida
Sakagami, Naoko
Ono, Noriaki
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/ncomms11277Metadata
Show full item recordCitation
Ono, Wanida, Naoko Sakagami, Shigeki Nishimori, Noriaki Ono, and Henry M. Kronenberg. 2016. “Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation.” Nature Communications 7 (1): 11277. doi:10.1038/ncomms11277. http://dx.doi.org/10.1038/ncomms11277.Abstract
Dental root formation is a dynamic process in which mesenchymal cells migrate toward the site of the future root, differentiate and secrete dentin and cementum. However, the identities of dental mesenchymal progenitors are largely unknown. Here we show that cells expressing osterix are mesenchymal progenitors contributing to all relevant cell types during morphogenesis. The majority of cells expressing parathyroid hormone-related peptide (PTHrP) are in the dental follicle and on the root surface, and deletion of its receptor (PPR) in these progenitors leads to failure of eruption and significantly truncated roots lacking periodontal ligaments. The PPR-deficient progenitors exhibit accelerated cementoblast differentiation with upregulation of nuclear factor I/C (Nfic). Deletion of histone deacetylase-4 (HDAC4) partially recapitulates the PPR deletion root phenotype. These findings indicate that PPR signalling in dental mesenchymal progenitors is essential for tooth root formation, underscoring importance of the PTHrP–PPR system during root morphogenesis and tooth eruption.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832076/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:26860068
Collections
- HMS Scholarly Articles [17293]
Contact administrator regarding this item (to report mistakes or request changes)