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dc.contributor.authorOno, Wanidaen_US
dc.contributor.authorSakagami, Naokoen_US
dc.contributor.authorNishimori, Shigekien_US
dc.contributor.authorOno, Noriakien_US
dc.contributor.authorKronenberg, Henry M.en_US
dc.date.accessioned2016-05-02T16:59:49Z
dc.date.issued2016en_US
dc.identifier.citationOno, Wanida, Naoko Sakagami, Shigeki Nishimori, Noriaki Ono, and Henry M. Kronenberg. 2016. “Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation.” Nature Communications 7 (1): 11277. doi:10.1038/ncomms11277. http://dx.doi.org/10.1038/ncomms11277.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26860068
dc.description.abstractDental root formation is a dynamic process in which mesenchymal cells migrate toward the site of the future root, differentiate and secrete dentin and cementum. However, the identities of dental mesenchymal progenitors are largely unknown. Here we show that cells expressing osterix are mesenchymal progenitors contributing to all relevant cell types during morphogenesis. The majority of cells expressing parathyroid hormone-related peptide (PTHrP) are in the dental follicle and on the root surface, and deletion of its receptor (PPR) in these progenitors leads to failure of eruption and significantly truncated roots lacking periodontal ligaments. The PPR-deficient progenitors exhibit accelerated cementoblast differentiation with upregulation of nuclear factor I/C (Nfic). Deletion of histone deacetylase-4 (HDAC4) partially recapitulates the PPR deletion root phenotype. These findings indicate that PPR signalling in dental mesenchymal progenitors is essential for tooth root formation, underscoring importance of the PTHrP–PPR system during root morphogenesis and tooth eruption.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/ncomms11277en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832076/pdf/en
dash.licenseLAAen_US
dc.titleParathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorNishimori, Shigekien_US
dc.date.available2016-05-02T16:59:49Z
dc.identifier.doi10.1038/ncomms11277*
dash.authorsorderedfalse
dash.contributor.affiliatedKronenberg, Henry
dash.contributor.affiliatedNishimori, Shigeki


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