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dc.contributor.authorYang, Jianen_US
dc.contributor.authorBakshi, Andrewen_US
dc.contributor.authorZhu, Zhihongen_US
dc.contributor.authorHemani, Gibranen_US
dc.contributor.authorVinkhuyzen, Anna A.E.en_US
dc.contributor.authorLee, Sang Hongen_US
dc.contributor.authorRobinson, Matthew R.en_US
dc.contributor.authorPerry, John R.B.en_US
dc.contributor.authorNolte, Ilja M.en_US
dc.contributor.authorvan Vliet-Ostaptchouk, Jana V.en_US
dc.contributor.authorSnieder, Harolden_US
dc.contributor.authorEsko, Tonuen_US
dc.contributor.authorMilani, Lilien_US
dc.contributor.authorMägi, Reediken_US
dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorHamsten, Andersen_US
dc.contributor.authorMagnusson, Patrik K.E.en_US
dc.contributor.authorPedersen, Nancy L.en_US
dc.contributor.authorIngelsson, Eriken_US
dc.contributor.authorSoranzo, Nicoleen_US
dc.contributor.authorKeller, Matthew C.en_US
dc.contributor.authorWray, Naomi R.en_US
dc.contributor.authorGoddard, Michael E.en_US
dc.contributor.authorVisscher, Peter M.en_US
dc.date.accessioned2016-05-02T16:59:55Z
dc.date.issued2015en_US
dc.identifier.citationYang, J., A. Bakshi, Z. Zhu, G. Hemani, A. A. Vinkhuyzen, S. H. Lee, M. R. Robinson, et al. 2015. “Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.” Nature genetics 47 (10): 1114-1120. doi:10.1038/ng.3390. http://dx.doi.org/10.1038/ng.3390.en
dc.identifier.issn1061-4036en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26860080
dc.description.abstractWe propose a method (GREML-LDMS) to estimate heritability for human complex traits in unrelated individuals using whole-genome sequencing (WGS) data. We demonstrate using simulations based on WGS data that ~97% and ~68% of variation at common and rare variants, respectively, can be captured by imputation. Using the GREML-LDMS method, we estimate from 44,126 unrelated individuals that all ~17M imputed variants explain 56% (s.e. = 2.3%) of variance for height and 27% (s.e. = 2.5%) for body mass index (BMI), and find evidence that height- and BMI-associated variants have been under natural selection. Considering imperfect tagging of imputation and potential overestimation of heritability from previous family-based studies, heritability is likely to be 60–70% for height and 30–40% for BMI. Therefore, missing heritability is small for both traits. For further gene discovery of complex traits, a design with SNP arrays followed by imputation is more cost-effective than WGS at current prices.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ng.3390en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589513/pdf/en
dash.licenseLAAen_US
dc.titleGenetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass indexen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature geneticsen
dash.depositing.authorEsko, Tonuen_US
dc.date.available2016-05-02T16:59:55Z
dc.identifier.doi10.1038/ng.3390*
dash.authorsorderedfalse
dash.contributor.affiliatedEsko, Tõnu
dc.identifier.orcid0000-0003-1982-6569


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