NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin

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NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin

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Title: NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin
Author: Chiasson-MacKenzie, Christine; Morris, Zachary S.; Baca, Quentin; Morris, Brett; Coker, Joanna K.; Mirchev, Rossen; Jensen, Anne E.; Carey, Thomas; Stott, Shannon L.; Golan, David E.; McClatchey, Andrea I.

Note: Order does not necessarily reflect citation order of authors.

Citation: Chiasson-MacKenzie, C., Z. S. Morris, Q. Baca, B. Morris, J. K. Coker, R. Mirchev, A. E. Jensen, et al. 2015. “NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.” The Journal of Cell Biology 211 (2): 391-405. doi:10.1083/jcb.201503081. http://dx.doi.org/10.1083/jcb.201503081.
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Abstract: The proliferation of normal cells is inhibited at confluence, but the molecular basis of this phenomenon, known as contact-dependent inhibition of proliferation, is unclear. We previously identified the neurofibromatosis type 2 (NF2) tumor suppressor Merlin as a critical mediator of contact-dependent inhibition of proliferation and specifically found that Merlin inhibits the internalization of, and signaling from, the epidermal growth factor receptor (EGFR) in response to cell contact. Merlin is closely related to the membrane–cytoskeleton linking proteins Ezrin, Radixin, and Moesin, and localization of Merlin to the cortical cytoskeleton is required for contact-dependent regulation of EGFR. We show that Merlin and Ezrin are essential components of a mechanism whereby mechanical forces associated with the establishment of cell–cell junctions are transduced across the cell cortex via the cortical actomyosin cytoskeleton to control the lateral mobility and activity of EGFR, providing novel insight into how cells inhibit mitogenic signaling in response to cell contact.
Published Version: doi:10.1083/jcb.201503081
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621825/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:26860149
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