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dc.contributor.authorG Ladep, Nimzing
dc.contributor.authorAgbahi, Oche O
dc.contributor.authorAgaba, Patricia A
dc.contributor.authorMuazu, Auwal
dc.contributor.authorUgoagwu, Placid
dc.contributor.authorImade, Godwin
dc.contributor.authorCooke, Graham S.
dc.contributor.authorVivas, Livia
dc.contributor.authorMcCormack, Sheena
dc.contributor.authorTaylor-Robinson, Simon D
dc.contributor.authorIdoko, John
dc.contributor.authorKanki, Phyllis Jean
dc.date.accessioned2016-05-03T18:52:21Z
dc.date.issued2013
dc.identifier.citationG Ladep, Nimzing, et all. 2013. “Hepatitis B Co-Infection Is Associated with Poorer Survival of HIV-Infected Patients on Highly Active Antiretroviral Therapy in West Africa.” Journal of AIDS & Clinical Research 01 (S3). doi:10.4172/2155-6113.s3-006.en_US
dc.identifier.issn2155-6113en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26878043
dc.description.abstractBackground: Hepatitis B has been reported to be high in HIV-infected African populations. However, the impact of this co-infection on the survival of HIV-infected Africans on long-term highly active antiretroviral therapy (HAART) remains poorly characterised. We investigated the impact of HBV/HIV co-infection on survival of HIV infected patients undergoing antiretroviral therapy in a West African population. Methods: This was a clinic-based cohort study of HIV-infected adults enrolled in Nigeria, West Africa. Study subjects (9,758) were screened for hepatitis B and hepatitis C at HAART initiation. Kaplan-Meier survival and Cox proportional hazards models were used to estimate probability of survival and to identify predictors of mortality respectively, based on hepatitis B surface antigen status. All patients had signed an informed written consent before enrolment into the study; and we additionally obtained permission for secondary use of data from the Harvard institutional review board. Results: Patients were followed up for a median of 41 months (interquartile range: 30–62 months) during which, 181 (1.9%) patients died. Most of the deaths; 143 (79.0%) occurred prior to availability of Tenofovir. Among those that were on antiretroviral therapy, hepatitis B co-infected patients experienced a significantly lower survival than HIV mono-infected patients at 74 months of follow up (94% vs. 97%; p=0.0097). Generally, hepatitis B co-infection: HBsAg-positive/HIV-positive (Hazards Rate [HR]; 1.5: 95% CI 1.09–2.11), co-morbid tuberculosis (HR; 2.2: 95% CI 1.57–2.96) and male gender (HR; 1.5: 95% CI 1.08–2.00) were significantly predictive of mortality. Categorising the patients based on use of Tenofovir, HBV infection failed to become a predictor of mortality among those on Tenofovir-containing HAART. Conclusions: HBsAg-positive status was associated with reduced survival and was an independent predictor of mortality in this African HIV cohort on HAART. However, Tenofovir annulled the impact of HBV on mortality of HIV patients in the present study cohort.en_US
dc.language.isoen_USen_US
dc.publisherOMICS Publishing Groupen_US
dc.relation.isversionofdoi:10.4172/2155-6113.S3-006en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199237/en_US
dash.licenseOAP
dc.subjectmortalityen_US
dc.subjecthepatitis B surface antigenen_US
dc.subjectHIVen_US
dc.subjectCD4en_US
dc.subjectHAARTen_US
dc.subjectsurvivalen_US
dc.subjectAfricaen_US
dc.titleHepatitis B Co-Infection is Associated with Poorer Survival of HIV-Infected Patients on Highly Active Antiretroviral Therapy in West Africaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalJ AIDS Clin Resen_US
dash.depositing.authorKanki, Phyllis Jean
dc.date.available2016-05-03T18:52:21Z
dash.funder.nameUS Health Resources and Services Administrationen_US
dash.funder.nameNIHen_US
dash.funder.awardU51HA02522-01-01en_US
dash.funder.awardR24TW008878en_US
dc.identifier.doi10.4172/2155-6113.S3-006*
dash.authorsorderedfalse
dash.contributor.affiliatedKanki, Phyllis


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