In Vitro Selection of Neisseria gonorrhoeae Mutants with Elevated MIC Values and Increased Resistance to Cephalosporins
Johnson, S. R.
Ganakammal, S. R.
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CitationJohnson, S. R., Y. Grad, S. R. Ganakammal, M. Burroughs, M. Frace, M. Lipsitch, R. Weil, and D. Trees. 2014. “In Vitro Selection of Neisseria Gonorrhoeae Mutants with Elevated MIC Values and Increased Resistance to Cephalosporins.” Antimicrobial Agents and Chemotherapy 58 (11) (September 8): 6986–6989. doi:10.1128/aac.03082-14. http://dx.doi.org/10.1128/AAC.03082-14.
AbstractStrains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with elevated MICs to cephalosporins. The first possesses a point mutation in the transpeptidase region of the mosaic penA gene, and the second contains an insertion mutation in pilQ.
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