Role of selenium in HIV infection

DSpace/Manakin Repository

Role of selenium in HIV infection

Citable link to this page


Title: Role of selenium in HIV infection
Author: Stone, Cosby A; Kawai, Kosuke; Kupka, Roland; Fawzi, Wafaie W.

Note: Order does not necessarily reflect citation order of authors.

Citation: Stone, Cosby A, Kosuke Kawai, Roland Kupka, and Wafaie W Fawzi. 2010. “Role of Selenium in HIV Infection.” Nutrition Reviews 68 (11) (October 20): 671–681. doi:10.1111/j.1753-4887.2010.00337.x.
Full Text & Related Files:
Abstract: HIV infection is a global disease that disproportionately burdens populations with nutritional vulnerabilities. Laboratory experiments have shown that selenium has an inhibitory effect on HIV in vitro through antioxidant effects of glutathione peroxidase and other selenoproteins. Numerous studies have reported low selenium status in HIV-infected individuals, and serum selenium concentration declines with disease progression. Some cohort studies have shown an association between selenium deficiency and progression to AIDS or mortality. In several randomized controlled trials, selenium supplementation has reduced hospitalizations, diarrheal morbidity, and improved CD4 cell counts, but the evidence remains mixed. Additional trials are recommended to study the effect of selenium supplementation on opportunistic infections, and other HIV disease related comorbidities in the context of highly active antiretroviral therapy in both developing and developed countries.
Published Version: doi:10.1111/j.1753-4887.2010.00337.x
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search