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dc.contributor.authorFinkelstein, Julia
dc.contributor.authorMehta, Saurabh
dc.contributor.authorDuggan, Christopher Paul
dc.contributor.authorManji, Karim P.
dc.contributor.authorMugusi, Ferdinand M.
dc.contributor.authorAboud, Said
dc.contributor.authorSpiegelman, Donna Lynn
dc.contributor.authorMsamanga, Gernard I.
dc.contributor.authorFawzi, Wafaie W.
dc.date.accessioned2016-05-10T18:21:17Z
dc.date.issued2012
dc.identifier.citationFinkelstein, Julia L., Saurabh Mehta, Christopher Duggan, Karim P. Manji, Ferdinand M. Mugusi, Said Aboud, Donna Spiegelman, Gernard I. Msamanga, and Wafaie W. Fawzi. 2012. “Maternal Vitamin D Status and Child Morbidity, Anemia, and Growth in Human Immunodeficiency Virus-Exposed Children in Tanzania.” The Pediatric Infectious Disease Journal 31 (2) (February): 171–175. doi:10.1097/inf.0b013e318245636b.en_US
dc.identifier.issn0891-3668en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26978416
dc.description.abstractBackground Vitamin D may help prevent adverse pediatric outcomes, including infectious diseases and growth failure, based on its role in immune and metabolic functions. We examined the association of maternal vitamin D status and pediatric health outcomes in children born to HIV-infected women. Methods Vitamin D status was determined in 884 HIV-infected pregnant women at 12 to 27 weeks of gestation in a trial of vitamin supplementation (not including vitamin D) in Tanzania. Information on child morbidities, anemia and hypochromic microcytosis, and anthropometry was recorded through monthly clinic visits. Generalized estimated equations and Cox proportional hazards models were used to assess the relationships of outcomes with maternal vitamin D status. Results A total of 39% of women had low vitamin D levels (<32 ng/mL). Children born to women with low vitamin D status were 1.11 times more likely to report cough during follow-up (RR: 1.11; 95% CI: 1.02-1.21). No significant associations were noted for other respiratory symptoms, diarrhea, or anemia outcomes. Low maternal vitamin D status was associated with significantly increased risk of stunting (height-for-age z-score <-2; RR: 1.29; 95% CI: 1.05-1.59) and underweight (weight-for-age z-score <-2; RR: 1.33; 95% CI: 1.03-1.71). Conclusions Maternal vitamin D status may be an important risk factor for respiratory infections, and ensuring optimal growth in HIV-exposed children.en_US
dc.language.isoen_USen_US
dc.publisherOvid Technologies (Wolters Kluwer Health)en_US
dc.relation.isversionofdoi:10.1097/INF.0b013e318245636ben_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813463/en_US
dash.licenseLAA
dc.subjectVitamin Den_US
dc.subjectMorbidityen_US
dc.subjectAnemiaen_US
dc.subjectGrowthen_US
dc.subjectChildrenen_US
dc.subjectHIV/AIDSen_US
dc.titleMaternal Vitamin D Status and Child Morbidity, Anemia, and Growth in Human Immunodeficiency Virus-exposed Children in Tanzaniaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalThe Pediatric Infectious Disease Journalen_US
dash.depositing.authorFawzi, Wafaie W.
dc.date.available2016-05-10T18:21:17Z
dc.identifier.doi10.1097/INF.0b013e318245636b*
dash.contributor.affiliatedDuggan, Christopher
dash.contributor.affiliatedFinkelstein, Julia
dash.contributor.affiliatedFawzi, Wafaie
dash.contributor.affiliatedSpiegelman, Donna
dc.identifier.orcid0000-0002-2908-600X
dc.identifier.orcid0000-0003-4006-4650


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