Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model
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CitationTrzcinski, K., C. Thompson, R. Malley, and M. Lipsitch. 2005. “Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection Against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model.” Infection and Immunity 73 (10) (September 21): 7043–7046. doi:10.1128/iai.73.10.7043-7046.2005.
AbstractIn mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4+ T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.
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