CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization

DSpace/Manakin Repository

CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization

Citable link to this page

 

 
Title: CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization
Author: Malley, Richard; Trzcinski, K.; Srivastava, Amit; Thompson, Claudette M.; Anderson, Porter; Lipsitch, Marc

Note: Order does not necessarily reflect citation order of authors.

Citation: Malley, R., K. Trzcinski, A. Srivastava, C. M. Thompson, P. W. Anderson, and M. Lipsitch. 2005. “CD4+ T Cells Mediate Antibody-Independent Acquired Immunity to Pneumococcal Colonization.” Proceedings of the National Academy of Sciences 102 (13) (March 21): 4848–4853. doi:10.1073/pnas.0501254102.
Full Text & Related Files:
Abstract: Acquired immunity to Streptococcus pneumoniae (pneumococcus) has long been assumed to depend on the presence of anticapsular antibodies. We found, however, that colonization with live pneumococci of serotypes 6B, 7F, or 14 protected mice against recolonization by any of the serotypes and that protection from acquisition of a heterologous or homologous strain did not depend on anticapsular antibody. Further, intranasal immunization by live pneumococcal colonization or by a killed, nonencapsulated whole-cell vaccine protected antibody-deficient mice against colonization, suggesting independence of antibodies to any pneumococcal antigens. Protection by intranasal immunization with whole-cell vaccine was completely abrogated in T cell-deficient mice, and in mice that were congenitally deficient in CD4+ T cells or depleted of these cells at the time of challenge. In contrast, mice congenitally deficient in, or depleted of, CD8+ T cells were fully protected. Protection in this model was observed beyond 2 months after immunization, arguing against innate or nonspecific immune mechanisms. Thus, we find that immunity to pneumococcal colonization can be induced in the absence of antibody, independent of the capsular type, and this protection requires the presence of CD4+ T cells at the time of challenge.
Published Version: doi:10.1073/pnas.0501254102
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC555733/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:26978426
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters