De novo cis-regulatory module elicitation for eukaryotic genomes

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De novo cis-regulatory module elicitation for eukaryotic genomes

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Title: De novo cis-regulatory module elicitation for eukaryotic genomes
Author: Gupta, M.; Liu, Jun

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Citation: Gupta, M., and J. S. Liu. 2005. “De Novo Cis-Regulatory Module Elicitation for Eukaryotic Genomes.” Proceedings of the National Academy of Sciences 102 (20) (May 9): 7079–7084. doi:10.1073/pnas.0408743102.
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Abstract: Transcription regulation is controlled by coordinated binding of one or more transcription factors in the promoter regions of genes. In many species, especially higher eukaryotes, transcription factor binding sites tend to occur as homotypic or heterotypic clusters, also known as cis-regulatory modules. The number of sites and distances between the sites, however, vary greatly in a module. We propose a statistical model to describe the underlying cluster structure as well as individual motif conservation and develop a Monte Carlo motif screening strategy for predicting novel regulatory modules in upstream sequences of coregulated genes. We demonstrate the power of the method with examples ranging from bacterial to insect and human genomes.
Published Version: doi:10.1073/pnas.0408743102
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129096/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27002086
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