Delivery by caesarean section and risk of obesity in preschool age children: A prospective cohort study
Edwards, Janet W. Rich
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CitationHuh, S. Y., S. L. Rifas-Shiman, C. A. Zera, J. W. R. Edwards, E. Oken, S. T. Weiss, and M. W. Gillman. 2012. Delivery by caesarean section and risk of obesity in preschool age children: A prospective cohort study. Archives of Disease in Childhood 97, no. 7: 610–616. doi:10.1136/archdischild-2011-301141.
AbstractObjective: To examine whether delivery by caesarean section is a risk factor for childhood
Design: Prospective pre-birth cohort study (Project Viva).
Setting: Eight outpatient multi-specialty practices based in the Boston, Massachusetts area.
Participants: We recruited women during early pregnancy between 1999 and 2002, and followed their children after birth. We included 1255 children with body composition measured at 3 years of age.
Main outcome measures: Body mass index (BMI) z-score, obesity (BMI for age and sex ≥ 95th percentile), and sum of triceps + subscapular skinfold thicknesses, at 3 years of age.
Results: 284 children (22.6 percent) were delivered by caesarean section. At age 3, 15.7% of children delivered by caesarean section were obese, compared with 7.5% of children born vaginally. In multivariable logistic and linear regression models adjusting for maternal pre-pregnancy BMI, birth weight, and other covariates, birth by caesarean section was associated with a higher odds of obesity at age 3 (OR 2.10, 95%CI 1.36 to 3.23), higher mean BMI z-score (0.20 units, 95% CI 0.07 to 0.33), and higher sum of triceps + subscapular skinfold thicknesses (0.94 mm, 95% CI 0.36 to 1.51).
Conclusions: Infants delivered by caesarean section may be at increased risk of childhood obesity. Further studies are needed to confirm our findings and to explore mechanisms underlying this association.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27003770
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