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dc.contributor.authorBranco, Alan
dc.contributor.authorTao, Y
dc.contributor.authorHartl, Daniel L.
dc.contributor.authorSilva, Bernardo Lemos
dc.date.accessioned2016-05-20T15:25:46Z
dc.date.issued2013
dc.identifier.citationBranco, A T, Y Tao, D L Hartl, and B Lemos. 2013. Natural Variation of the Y Chromosome Suppresses Sex Ratio Distortion and Modulates Testis-Specific Gene Expression in Drosophila Simulans. Heredity 111, no. 1: 8–15.en_US
dc.identifier.issn0018-067Xen_US
dc.identifier.issn1365-2540en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27024101
dc.description.abstractX-linked sex-ratio distorters that disrupt spermatogenesis can cause a deficiency in functional Y-bearing sperm and a female-biased sex ratio. Y-linked modifiers that restore a normal sex ratio might be abundant and favored when a X-linked distorter is present. Here we investigated natural variation of Y-linked suppressors of sex-ratio in the Winters systems and the ability of these chromosomes to modulate gene expression in Drosophila simulans. Seventy-eight Y chromosomes of worldwide origin were assayed for their resistance to the X-linked sex-ratio distorter gene Dox. Y chromosome diversity caused males to sire ~63% to ~98% female progeny. Genome-wide gene expression analysis revealed hundreds of genes differentially expressed between isogenic males with sensitive (high sex ratio) and resistant (low sex ratio) Y chromosomes from the same population. Although the expression of about 75% of all testis-specific genes remained unchanged across Y chromosomes, a subset of post-meiotic genes was upregulated by resistant Y chromosomes. Conversely, a set of accessory gland-specific genes and mitochondrial genes were downregulated in males with resistant Y chromosomes. The D. simulans Y chromosome also modulated gene expression in XXY females in which the Y-linked protein-coding genes are not transcribed. The data suggest that the Y chromosome might exert its regulatory functions through epigenetic mechanisms that do not require the expression of protein-coding genes. The gene network that modulates sex ratio distortion by the Y chromosome is poorly understood, other than that it might include interactions with mitochondria and enriched for genes expressed in post-meiotic stages of spermatogenesis.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/hdy.2013.5en_US
dash.licenseMETA_ONLY
dc.subjectsex ratio distortionen_US
dc.subjectY chromosomeen_US
dc.subjectgene expressionen_US
dc.subjectspermatogenesisen_US
dc.subjectmitochondriaen_US
dc.titleNatural Variation of the Y Chromosome Suppresses Sex Ratio Distortion and Modulates Testis-Specific Gene Expression in Drosophila Simulansen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalHeredityen_US
dash.depositing.authorHartl, Daniel L.
dash.embargo.until10000-01-01
dash.affiliation.otherMolecular and Integrative Physiological Sciences, Environmental Health, Harvard School of Public Healthen_US
dc.identifier.doi10.1038/hdy.2013.5*
workflow.legacycommentsFAR 2014 oap.needman (MM) Hartl emailed 2016-05-05 ADen_US
dash.authorsorderedfalse
dash.contributor.affiliatedBranco, Alan
dash.contributor.affiliatedLemos, Bernardo
dash.contributor.affiliatedHartl, Daniel


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