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dc.contributor.authorCorbett-Detig, Russell B.
dc.contributor.authorZhou, Jun
dc.contributor.authorClark, Andrew G.
dc.contributor.authorHartl, Daniel L.
dc.contributor.authorAyroles, Julien
dc.date.accessioned2016-05-20T15:26:15Z
dc.date.issued2013
dc.identifier.citationCorbett-Detig, Russell B., Jun Zhou, Andrew G. Clark, Daniel L. Hartl, and Julien F. Ayroles. 2013. “Genetic Incompatibilities Are Widespread Within Species.” Nature 504 (7478) (November 6): 135–137.en_US
dc.identifier.issn0028-0836en_US
dc.identifier.issn1476-4687en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27024102
dc.description.abstractThe importance of epistasis—non-additive interactions between alleles—in shaping population fitness has long been a controversial topic, hampered in part by lack of empirical evidence1, 2, 3, 4. Traditionally, epistasis is inferred on the basis of non-independence of genotypic values between loci for a given trait. However, epistasis for fitness should also have a genomic footprint5, 6, 7. To capture this signal, we have developed a simple approach that relies on detecting genotype ratio distortion as a sign of epistasis, and we apply this method to a large panel of Drosophila melanogaster recombinant inbred lines8, 9. Here we confirm experimentally that instances of genotype ratio distortion represent loci with epistatic fitness effects; we conservatively estimate that any two haploid genomes in this study are expected to harbour 1.15 pairs of epistatically interacting alleles. This observation has important implications for speciation genetics, as it indicates that the raw material to drive reproductive isolation is segregating contemporaneously within species and does not necessarily require, as proposed by the Dobzhansky–Muller model, the emergence of incompatible mutations independently derived and fixed in allopatry. The relevance of our result extends beyond speciation, as it demonstrates that epistasis is widespread but that it may often go undetected owing to lack of statistical power or lack of genome-wide scope of the experiments.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/nature12678en_US
dc.relation.hasversionhttp://www.umich.edu/~zhanglab/clubPaper/02_13_2014.pdfen_US
dc.relation.hasversionhttp://www.readcube.com/articles/10.1038/nature12678en_US
dash.licenseMETA_ONLY
dc.subjectEvolutionary geneticsen_US
dc.subjectGenetic interactionen_US
dc.titleGenetic incompatibilities are widespread within speciesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNatureen_US
dash.depositing.authorHartl, Daniel L.
dash.embargo.until10000-01-01
dc.identifier.doi10.1038/nature12678*
workflow.legacycommentsRequest manuscript to be posted LAA with no embargo (Nature pub w/ waiver filed - pub date 5Dec2013) FAR 2014 oap.needman (MM) Hartl emailed 2016-05-05 ADen_US
dash.contributor.affiliatedAyroles, Julien
dash.contributor.affiliatedZhou, Jun
dash.contributor.affiliatedHartl, Daniel


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