dc.contributor.author | Branco, Alan | |
dc.contributor.author | Hartl, Daniel L. | |
dc.contributor.author | Silva, Bernardo Lemos | |
dc.date.accessioned | 2016-05-20T15:29:36Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Branco, A. T., D. L. Hartl, and B. Lemos. 2013. “Chromatin-Associated Proteins HP1 and Mod(mdg4) Modify Y-Linked Regulatory Variation in the Drosophila Testis.” Genetics 194 (3) (July 1): 609–618. | en_US |
dc.identifier.issn | 0016-6731 | en_US |
dc.identifier.issn | 1943-2631 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:27024104 | |
dc.description.abstract | Chromatin remodeling is crucial for gene regulation. Remodeling is often mediated through chemical modifications of the DNA template, DNA-associated proteins, and RNA-mediated processes. Y-linked regulatory variation (YRV) refers to the quantitative effects that polymorphic tracts of Y-linked chromatin exert on gene expression of X-linked and autosomal genes. Here we show that naturally occurring polymorphisms in the Drosophila melanogaster Y chromosome contribute disproportionally to gene expression variation in the testis. The variation is dependent on wild-type expression levels of mod(mdg4) as well as Su(var)205; the latter gene codes for heterochromatin protein 1 (HP1) in Drosophila. Testis-specific YRV is abolished in genotypes with heterozygous loss-of-function mutations for mod(mdg4) and Su(var)205 but not in similar experiments with JIL-1. Furthermore, the Y chromosome differentially regulates several ubiquitously expressed genes. The results highlight the requirement for wild-type dosage of Su(var)205 and mod(mdg4) in enabling naturally occurring Y-linked regulatory variation in the testis. The phenotypes that emerge in the context of wild-type levels of the HP1 and Mod(mdg4) proteins might be part of an adaptive response to the environment. | en_US |
dc.description.sponsorship | Organismic and Evolutionary Biology | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Genetics Society of America | en_US |
dc.relation.isversionof | doi:10.1534/genetics.113.150805 | en_US |
dash.license | META_ONLY | |
dc.subject | Cryptic variation | en_US |
dc.subject | Heterochromatin | en_US |
dc.subject | Spermatogenesis | en_US |
dc.subject | Y chromosome | en_US |
dc.title | Chromatin-Associated Proteins HP1 and Mod(mdg4) Modify Y-Linked Regulatory Variation in the Drosophila Testis | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Genetics | en_US |
dash.depositing.author | Hartl, Daniel L. | |
dash.embargo.until | 10000-01-01 | |
dash.affiliation.other | Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health | en_US |
dc.identifier.doi | 10.1534/genetics.113.150805 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Hartl, Daniel | |
dash.contributor.affiliated | Branco, Alan | |
dash.contributor.affiliated | Lemos, Bernardo | |