Covalently Functionalized Nanotubes as Nanometer-Sized Probes in Chemistry and Biology

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Covalently Functionalized Nanotubes as Nanometer-Sized Probes in Chemistry and Biology

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dc.contributor.author Cheung, Chin Li
dc.contributor.author Wong, Stanislaus S.
dc.contributor.author Joselevich, Ernesto
dc.contributor.author Woolley, Adam T.
dc.contributor.author Lieber, Charles
dc.date.accessioned 2009-03-24T09:14:03Z
dc.date.issued 1998
dc.identifier.citation Wong, Stanislaus S., Ernesto Joselevich, Adam T. Woolley, Chin Li Cheung, and Charles M. Lieber. 1998. Covalently functionalized nanotubes as nanometer-sized probes in chemistry and biology. Nature 394: 52-55. en
dc.identifier.issn 0302-2889 en
dc.identifier.issn 0028-0836 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:2710385
dc.description.abstract Carbon nanotubes combine a range of properties that make them well suited for use as probe tips in applications such as atomic force microscopy (AFM)1, 2, 3. Their high aspect ratio, for example, opens up the possibility of probing the deep crevices4 that occur in microelectronic circuits, and the small effective radius of nanotube tips significantly improves the lateral resolution beyond what can be achieved using commercial silicon tips5. Another characteristic feature of nanotubes is their ability to buckle elastically4, 6, which makes them very robust while limiting the maximum force that is applied to delicate organic and biological samples. Earlier investigations into the performance of nanotubes as scanning probe microscopy tips have focused on topographical imaging, but a potentially more significant issue is the question of whether nanotubes can be modified to create probes that can sense and manipulate matter at the molecular level7. Here we demonstrate that nanotube tips with the capability of chemical and biological discrimination can be created with acidic functionality and by coupling basic or hydrophobic functionalities or biomolecular probes to the carboxyl groups that are present at the open tip ends. We have used these modified nanotubes as AFM tips to titrate the acid and base groups, to image patterned samples based on molecular interactions, and to measure the binding force between single protein ligand pairs. As carboxyl groups are readily derivatized by a variety of reactions8, the preparation of a wide range of functionalized nanotube tips should be possible, thus creating molecular probes with potential applications in many areas of chemistry and biology. en
dc.description.sponsorship Chemistry and Chemical Biology en
dc.language.iso en_US en
dc.publisher Nature Publishing Group en
dc.relation.isversionof http://dx.doi.org/10.1038/27873 en
dash.license LAA
dc.title Covalently Functionalized Nanotubes as Nanometer-Sized Probes in Chemistry and Biology en
dc.relation.journal Nature en
dash.depositing.author Lieber, Charles

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