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dc.contributor.authorEdwards, Scott
dc.contributor.authorChesnut, Kye
dc.contributor.authorSatta, Yoko
dc.contributor.authorWakeland, Edward K.
dc.date.accessioned2009-03-24T17:43:21Z
dc.date.issued1997
dc.identifier.citationEdwards, Scott V., Kye Chesnut, Yoko Satta, and Edward K. Wakeland. 1997. Ancestral polymorphism of Mhc class II genes in mice: Implications for balancing selection and the mammalian molecular clock. Genetics 146(2): 655-668.en
dc.identifier.issn0016-6731en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:2710473
dc.description.abstractTo investigate the evolutionary dynamics at Mhc class II DR genes of mice (genus Mus),we sequenced the peptide binding regions (PBRs) of 41 DRB (=E beta) genes and eight DRA (=E alpha) genes from 15 strains representing eight species. As expected trees of these PER sequences imply extensive maintenance of ancestral DRB alleles across species. We use a coalescent simulation model to show that the number of interspecific coalescent events (c) observed on these trees was higher than the number expected for neutral genealogies and similar sample sizes and is more consistent with balancing selection than with neutrality. Patterns of ancestral polymorphism in mouse DRB alleles were also used to examine the tempo of synonymous substitution in the PER of mouse class II genes. Both absolute and relative rate tests on DRA and DRB genes imply increased substitution rates at two- and fourfold degnerate sites of mice and rats relative to primates, and decreased rates for the DRB genes of primates relative to ungulate and carnivore relatives. Thus rates of synonymous substitution at Mhc DR genes in mammals appear to be subject to generation time effects in ways similar to those found at other mammalian genes.en
dc.description.sponsorshipOrganismic and Evolutionary Biologyen
dc.language.isoen_USen
dc.publisherGenetics Society of Americaen
dc.relation.isversionofhttp://www.genetics.org/cgi/content/abstract/146/2/655en
dash.licenseMETA_ONLY
dc.titleAncestral Polymorphism of Mhc Class II Genes in Mice: Implications for Balancing Selection and the Mammalian Molecular Clocken
dc.relation.journalGeneticsen
dash.depositing.authorEdwards, Scott
dash.embargo.until10000-01-01
dash.contributor.affiliatedEdwards, Scott


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