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dc.contributor.authorSalazar, Juanen_US
dc.contributor.authorLuzardo, Elianaen_US
dc.contributor.authorMejías, José Carlosen_US
dc.contributor.authorRojas, Joselynen_US
dc.contributor.authorFerreira, Antonioen_US
dc.contributor.authorRivas-Ríos, José Ramónen_US
dc.contributor.authorBermúdez, Valmoreen_US
dc.date.accessioned2016-06-14T18:51:15Z
dc.date.issued2016en_US
dc.identifier.citationSalazar, Juan, Eliana Luzardo, José Carlos Mejías, Joselyn Rojas, Antonio Ferreira, José Ramón Rivas-Ríos, and Valmore Bermúdez. 2016. “Epicardial Fat: Physiological, Pathological, and Therapeutic Implications.” Cardiology Research and Practice 2016 (1): 1291537. doi:10.1155/2016/1291537. http://dx.doi.org/10.1155/2016/1291537.en
dc.identifier.issn2090-8016en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27320190
dc.description.abstractEpicardial fat is closely related to blood supply vessels, both anatomically and functionally, which is why any change in this adipose tissue's behavior is considered a potential risk factor for cardiovascular disease development. When proinflammatory adipokines are released from the epicardial fat, this can lead to a decrease in insulin sensitivity, low adiponectin production, and an increased proliferation of vascular smooth muscle cells. These adipokines move from one compartment to another by either transcellular passing or diffusion, thus having the ability to regulate cardiac muscle activity, a phenomenon called vasocrine regulation. The participation of these adipokines generates a state of persistent vasoconstriction, increased stiffness, and weakening of the coronary wall, consequently contributing to the formation of atherosclerotic plaques. Therefore, epicardial adipose tissue thickening should be considered a risk factor in the development of cardiovascular disease, a potential therapeutic target for cardiovascular pathology and a molecular point of contact for “endocrine-cardiology.”en
dc.language.isoen_USen
dc.publisherHindawi Publishing Corporationen
dc.relation.isversionofdoi:10.1155/2016/1291537en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861775/pdf/en
dash.licenseLAAen_US
dc.titleEpicardial Fat: Physiological, Pathological, and Therapeutic Implicationsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalCardiology Research and Practiceen
dc.date.available2016-06-14T18:51:15Z
dc.identifier.doi10.1155/2016/1291537*


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