An inter‐species protein–protein interaction network across vast evolutionary distance
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Author
Zhong, Quan
Pevzner, Samuel J
Hao, Tong
Mosca, Roberto
Menche, Jörg
Taipale, Mikko
Taşan, Murat
Fan, Changyu
Yang, Xinping
Haley, Patrick
Murray, Ryan R
Mer, Flora
MacWilliams, Andrew
Dricot, Amélie
Reichert, Patrick
Santhanam, Balaji
Ghamsari, Lila
Rolland, Thomas
Charloteaux, Benoit
Lindquist, Susan
Barabási, Albert‐László
Aloy, Patrick
Cusick, Michael E
Xia, Yu
Roth, Frederick P
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.15252/msb.20156484Metadata
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Zhong, Q., S. J. Pevzner, T. Hao, Y. Wang, R. Mosca, J. Menche, M. Taipale, et al. 2016. “An inter‐species protein–protein interaction network across vast evolutionary distance.” Molecular Systems Biology 12 (4): 865. doi:10.15252/msb.20156484. http://dx.doi.org/10.15252/msb.20156484.Abstract
Abstract In cellular systems, biophysical interactions between macromolecules underlie a complex web of functional interactions. How biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional interactions, and how such biophysical‐versus‐functional network coordination is shaped by evolutionary forces are all largely unanswered questions. Here, we investigate these questions using an “inter‐interactome” approach. We systematically probed the yeast and human proteomes for interactions between proteins from these two species and functionally characterized the resulting inter‐interactome network. After a billion years of evolutionary divergence, the yeast and human proteomes are still capable of forming a biophysical network with properties that resemble those of intra‐species networks. Although substantially reduced relative to intra‐species networks, the levels of functional overlap in the yeast–human inter‐interactome network uncover significant remnants of co‐functionality widely preserved in the two proteomes beyond human–yeast homologs. Our data support evolutionary selection against biophysical interactions between proteins with little or no co‐functionality. Such non‐functional interactions, however, represent a reservoir from which nascent functional interactions may arise.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848758/pdf/Terms of Use
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