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dc.contributor.authorPlascencia-Villa, Germánen_US
dc.contributor.authorPonce, Arturoen_US
dc.contributor.authorCollingwood, Joanna F.en_US
dc.contributor.authorArellano-Jiménez, M. Josefinaen_US
dc.contributor.authorZhu, Xiongweien_US
dc.contributor.authorRogers, Jack T.en_US
dc.contributor.authorBetancourt, Israelen_US
dc.contributor.authorJosé-Yacamán, Miguelen_US
dc.contributor.authorPerry, Georgeen_US
dc.date.accessioned2016-06-14T18:51:18Z
dc.date.issued2016en_US
dc.identifier.citationPlascencia-Villa, Germán, Arturo Ponce, Joanna F. Collingwood, M. Josefina Arellano-Jiménez, Xiongwei Zhu, Jack T. Rogers, Israel Betancourt, Miguel José-Yacamán, and George Perry. 2016. “High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s disease.” Scientific Reports 6 (1): 24873. doi:10.1038/srep24873. http://dx.doi.org/10.1038/srep24873.en
dc.identifier.issn2045-2322en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27320196
dc.description.abstractAbnormal accumulation of brain metals is a key feature of Alzheimer’s disease (AD). Formation of amyloid-β plaque cores (APC) is related to interactions with biometals, especially Fe, Cu and Zn, but their particular structural associations and roles remain unclear. Using an integrative set of advanced transmission electron microscopy (TEM) techniques, including spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM), nano-beam electron diffraction, electron holography and analytical spectroscopy techniques (EDX and EELS), we demonstrate that Fe in APC is present as iron oxide (Fe3O4) magnetite nanoparticles. Here we show that Fe was accumulated primarily as nanostructured particles within APC, whereas Cu and Zn were distributed through the amyloid fibers. Remarkably, these highly organized crystalline magnetite nanostructures directly bound into fibrillar Aβ showed characteristic superparamagnetic responses with saturated magnetization with circular contours, as observed for the first time by off-axis electron holography of nanometer scale particles.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/srep24873en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848473/pdf/en
dash.licenseLAAen_US
dc.titleHigh-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s diseaseen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dash.depositing.authorRogers, Jack T.en_US
dc.date.available2016-06-14T18:51:18Z
dc.identifier.doi10.1038/srep24873*
dash.contributor.affiliatedRogers, Jack


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