Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit
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D'Agostino, Giuseppe
Lyons, David J
Cristiano, Claudia
Burke, Luke K
Garcia, Ana Paula
Land, Benjamin B
Dileone, Ralph J
Heisler, Lora K
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.7554/eLife.12225Metadata
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D'Agostino, G., D. J. Lyons, C. Cristiano, L. K. Burke, J. C. Madara, J. N. Campbell, A. P. Garcia, et al. 2016. “Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.” eLife 5 (1): e12225. doi:10.7554/eLife.12225. http://dx.doi.org/10.7554/eLife.12225.Abstract
The nucleus of the solitary tract (NTS) is a key gateway for meal-related signals entering the brain from the periphery. However, the chemical mediators crucial to this process have not been fully elucidated. We reveal that a subset of NTS neurons containing cholecystokinin (CCKNTS) is responsive to nutritional state and that their activation reduces appetite and body weight in mice. Cell-specific anterograde tracing revealed that CCKNTS neurons provide a distinctive innervation of the paraventricular nucleus of the hypothalamus (PVH), with fibers and varicosities in close apposition to a subset of melanocortin-4 receptor (MC4RPVH) cells, which are also responsive to CCK. Optogenetic activation of CCKNTS axon terminals within the PVH reveal the satiating function of CCKNTS neurons to be mediated by a CCKNTS→PVH pathway that also encodes positive valence. These data identify the functional significance of CCKNTS neurons and reveal a sufficient and discrete NTS to hypothalamus circuit controlling appetite. DOI: http://dx.doi.org/10.7554/eLife.12225.001Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861598/pdf/Terms of Use
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