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dc.contributor.authorTerauchi, Akikoen_US
dc.contributor.authorJohnson-Venkatesh, Erin Men_US
dc.contributor.authorBullock, Brennaen_US
dc.contributor.authorLehtinen, Maria Ken_US
dc.contributor.authorUmemori, Hisashien_US
dc.date.accessioned2016-06-14T18:51:21Z
dc.date.issued2016en_US
dc.identifier.citationTerauchi, Akiko, Erin M Johnson-Venkatesh, Brenna Bullock, Maria K Lehtinen, and Hisashi Umemori. 2016. “Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain.” eLife 5 (1): e12151. doi:10.7554/eLife.12151. http://dx.doi.org/10.7554/eLife.12151.en
dc.identifier.issn2050-084Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27320201
dc.description.abstractCommunication between pre- and postsynaptic cells promotes the initial organization of synaptic specializations, but subsequent synaptic stabilization requires transcriptional regulation. Here we show that fibroblast growth factor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2) for the stabilization of presynaptic terminals. FGF22 is released from CA3 pyramidal neurons and organizes the differentiation of excitatory nerve terminals formed onto them. Local application of FGF22 on the axons of dentate granule cells (DGCs), which are presynaptic to CA3 pyramidal neurons, induces IGF2 in the DGCs. IGF2, in turn, localizes to DGC presynaptic terminals and stabilizes them in an activity-dependent manner. IGF2 application rescues presynaptic defects of Fgf22-/- cultures. IGF2 is dispensable for the initial presynaptic differentiation, but is required for the following presynaptic stabilization both in vitro and in vivo. These results reveal a novel feedback signal that is critical for the activity-dependent stabilization of presynaptic terminals in the mammalian hippocampus. DOI: http://dx.doi.org/10.7554/eLife.12151.001en
dc.language.isoen_USen
dc.publishereLife Sciences Publications, Ltden
dc.relation.isversionofdoi:10.7554/eLife.12151en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868541/pdf/en
dash.licenseLAAen_US
dc.subjectsynaptic stabilizationen
dc.subjectfeedback signalingen
dc.subjectneural activityen
dc.subjectpresynaptic organizeren
dc.subjecttranscriptional regulationen
dc.subjecthippocampusen
dc.subjectMouseen
dc.titleRetrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brainen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journaleLifeen
dash.depositing.authorTerauchi, Akikoen_US
dc.date.available2016-06-14T18:51:21Z
dc.identifier.doi10.7554/eLife.12151*
dash.contributor.affiliatedTerauchi, Akiko
dash.contributor.affiliatedLehtinen, Maria
dash.contributor.affiliatedUmemori, Hisashi


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