Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
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Author
Collins, Nicholas
Jiang, Xiaodong
Zaid, Ali
Macleod, Bethany L.
Li, Jane
Park, Chang Ook
Haque, Ashraful
Bedoui, Sammy
Heath, William R.
Mueller, Scott N.
Gebhardt, Thomas
Carbone, Francis R.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ncomms11514Metadata
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Collins, N., X. Jiang, A. Zaid, B. L. Macleod, J. Li, C. O. Park, A. Haque, et al. 2016. “Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation.” Nature Communications 7 (1): 11514. doi:10.1038/ncomms11514. http://dx.doi.org/10.1038/ncomms11514.Abstract
Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4+ T cells in mouse skin are in equilibrium with the circulation at steady state. These cells are dispersed throughout the inter-follicular regions of the dermis and form clusters with antigen presenting cells around hair follicles. After infection or administration of a contact sensitizing agent, there is a sustained increase in skin CD4+ T-cell content, which is confined to the clusters, with a concomitant CCL5-dependent increase in CD4+ T-cell recruitment. Skin CCL5 is derived from CD11b+ cells and CD8+ T cells, with the elimination of the latter decreasing CD4+ T-cell numbers. These results reveal a complex pattern of tissue-retention and equilibration for CD4+ memory T cells in skin, which is altered by infection and inflammation history.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866325/pdf/Terms of Use
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