Canonical Genetic Signatures of the Adult Human Brain
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Author
Hawrylycz, Michael
Miller, Jeremy A.
Menon, Vilas
Feng, David
Dolbeare, Tim
Guillozet-Bongaarts, Angela L.
Jegga, Anil G.
Aronow, Bruce J.
Lee, Chang-Kyu
Bernard, Amy
Glasser, Matthew F.
Dierker, Donna L.
Menche, Jörge
Szafer, Aaron
Collman, Forrest
Grange, Pascal
Berman, Kenneth A.
Mihalas, Stefan
Yao, Zizhen
Stewart, Lance
Barabási, Albert-László
Schulkin, Jay
Phillips, John
Ng, Lydia
Dang, Chinh
Haynor, David R.
Jones, Allan
Van Essen, David C.
Koch, Christof
Lein, Ed
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/nn.4171Metadata
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Hawrylycz, M., J. A. Miller, V. Menon, D. Feng, T. Dolbeare, A. L. Guillozet-Bongaarts, A. G. Jegga, et al. 2015. “Canonical Genetic Signatures of the Adult Human Brain.” Nature neuroscience 18 (12): 1832-1844. doi:10.1038/nn.4171. http://dx.doi.org/10.1038/nn.4171.Abstract
The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure, and function. We applied a correlation-based metric of “differential stability” (DS) to assess reproducibility of gene expression patterning across 132 structures in six individual brains, revealing meso-scale genetic organization. The highest DS genes are highly biologically relevant, with enrichment for brain-related biological annotations, disease associations, drug targets, and literature citations. Using high DS genes we identified 32 anatomically diverse and reproducible gene expression signatures, which represent distinct cell types, intracellular components, and/or associations with neurodevelopmental and neurodegenerative disorders. Genes in neuron-associated compared to non-neuronal networks showed higher preservation between human and mouse; however, many diversely-patterned genes displayed dramatic shifts in regulation between species. Finally, highly consistent transcriptional architecture in neocortex is correlated with resting state functional connectivity, suggesting a link between conserved gene expression and functionally relevant circuitry.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700510/pdf/Terms of Use
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