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dc.contributor.authorSadeh, Naomien_US
dc.contributor.authorSpielberg, Jeffrey M.en_US
dc.contributor.authorLogue, Mark W.en_US
dc.contributor.authorWolf, Erika J.en_US
dc.contributor.authorSmith, Alicia K.en_US
dc.contributor.authorLusk, Joannaen_US
dc.contributor.authorHayes, Jasmeet P.en_US
dc.contributor.authorSperbeck, Emilyen_US
dc.contributor.authorMilberg, William P.en_US
dc.contributor.authorMcGlinchey, Regina E.en_US
dc.contributor.authorSalat, David H.en_US
dc.contributor.authorCarter, Weleetka C.en_US
dc.contributor.authorStone, Annjanetteen_US
dc.contributor.authorSchichman, Steven A.en_US
dc.contributor.authorHumphries, Donald E.en_US
dc.contributor.authorMiller, Mark W.en_US
dc.date.accessioned2016-06-14T18:52:13Z
dc.date.issued2015en_US
dc.identifier.citationSadeh, N., J. M. Spielberg, M. W. Logue, E. J. Wolf, A. K. Smith, J. Lusk, J. P. Hayes, et al. 2015. “SKA2 Methylation is associated with Decreased Prefrontal Cortical Thickness and Greater PTSD Severity among Trauma-Exposed Veterans.” Molecular psychiatry 21 (3): 357-363. doi:10.1038/mp.2015.134. http://dx.doi.org/10.1038/mp.2015.134.en
dc.identifier.issn1359-4184en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27320327
dc.description.abstractMethylation of the SKA2 gene has recently been identified as a promising biomarker of suicide risk. Based on this finding, we examined associations between SKA2 methylation, cortical thickness, and psychiatric phenotypes linked to suicide in trauma-exposed veterans. 200 trauma-exposed white non-Hispanic veterans of the recent conflicts in Iraq and Afghanistan (91% male) underwent clinical assessment and had blood drawn for genotyping and methylation analysis. 145 participants also had neuroimaging data available. Based on previous research, we examined DNA methylation at the CpG locus cg13989295 as well as DNA methylation adjusted for genotype at the methylation-associated SNP (rs7208505) in relationship to whole-brain cortical thickness, posttraumatic stress disorder symptoms (PTSD), and depression symptoms. Whole-brain vertex-wise analyses identified three clusters in prefrontal cortex that were associated with genotype-adjusted SKA2 DNA methylation (methylationadj). Specifically, DNA methylationadj was associated with bilateral reductions of cortical thickness in frontal pole and superior frontal gyrus, and similar effects were found in the right orbitofrontal cortex and right inferior frontal gyrus. PTSD symptom severity was positively correlated with SKA2 DNA methylationadj and negatively correlated with cortical thickness in these regions. Mediation analyses showed a significant indirect effect of PTSD on cortical thickness via SKA2 methylation status. Results suggest that DNA methylationadj of SKA2 in blood indexes stress-related psychiatric phenotypes and neurobiology, pointing to its potential value as a biomarker of stress exposure and susceptibility.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/mp.2015.134en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760869/pdf/en
dash.licenseLAAen_US
dc.subjecten
dc.subjectcortical thicknessen
dc.subjectmethylationen
dc.subjecttraumaen
dc.subjectposttraumatic stressen
dc.titleSKA2 Methylation is associated with Decreased Prefrontal Cortical Thickness and Greater PTSD Severity among Trauma-Exposed Veteransen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalMolecular psychiatryen
dash.depositing.authorMilberg, William P.en_US
dc.date.available2016-06-14T18:52:13Z
dc.identifier.doi10.1038/mp.2015.134*
dash.authorsorderedfalse
dash.contributor.affiliatedMcGlinchey, Regina
dash.contributor.affiliatedMilberg, William
dash.contributor.affiliatedSalat, David


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