Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia

DSpace/Manakin Repository

Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia

Citable link to this page

 

 
Title: Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia
Author: Wright, C; Gupta, C N; Chen, J; Patel, V; Calhoun, V D; Ehrlich, S; Wang, L; Bustillo, J R; Perrone-Bizzozero, N I; Turner, J A

Note: Order does not necessarily reflect citation order of authors.

Citation: Wright, C, C N Gupta, J Chen, V Patel, V D Calhoun, S Ehrlich, L Wang, J R Bustillo, N I Perrone-Bizzozero, and J A Turner. 2016. “Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia.” Translational Psychiatry 6 (2): e724. doi:10.1038/tp.2015.211. http://dx.doi.org/10.1038/tp.2015.211.
Full Text & Related Files:
Abstract: Evidence suggests that microRNA-137 (miR-137) is involved in the genetic basis of schizophrenia. Risk variants within the miR-137 host gene (MIR137HG) influence structural and functional brain-imaging measures, and miR-137 itself is predicted to regulate hundreds of genes. We evaluated the influence of a MIR137HG risk variant (rs1625579) in combination with variants in miR-137-regulated genes TCF4, PTGS2, MAPK1 and MAPK3 on gray matter concentration (GMC). These genes were selected based on our previous work assessing schizophrenia risk within possible miR-137-regulated gene sets using the same cohort of subjects. A genetic risk score (GRS) was determined based on genotypes of these four schizophrenia risk-associated genes in 221 Caucasian subjects (89 schizophrenia patients and 132 controls). The effects of the rs1625579 genotype with the GRS of miR-137-regulated genes in a three-way interaction with diagnosis on GMC patterns were assessed using a multivariate analysis. We found that schizophrenia subjects homozygous for the MIR137HG risk allele show significant decreases in occipital, parietal and temporal lobe GMC with increasing miR-137-regulated GRS, whereas those carrying the protective minor allele show significant increases in GMC with GRS. No correlations of GMC and GRS were found in control subjects. Variants within or upstream of genes regulated by miR-137 in combination with the MIR137HG risk variant may influence GMC in schizophrenia-related regions in patients. Given that the genes evaluated here are involved in protein kinase A signaling, dysregulation of this pathway through alterations in miR-137 biogenesis may underlie the gray matter loss seen in the disease.
Published Version: doi:10.1038/tp.2015.211
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872419/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27320362
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters