dc.contributor.author | Le, Thao Phuong | en_US |
dc.contributor.author | Vuong, Linh Thuong | en_US |
dc.contributor.author | Kim, Ah-Ram | en_US |
dc.contributor.author | Hsu, Ya-Chieh | en_US |
dc.contributor.author | Choi, Kwang-Wook | en_US |
dc.date.accessioned | 2016-06-14T18:52:38Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Le, Thao Phuong, Linh Thuong Vuong, Ah-Ram Kim, Ya-Chieh Hsu, and Kwang-Wook Choi. 2016. “14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila.” Nature Communications 7 (1): 11501. doi:10.1038/ncomms11501. http://dx.doi.org/10.1038/ncomms11501. | en |
dc.identifier.issn | 2041-1723 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:27320373 | |
dc.description.abstract | 14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, translationally controlled tumour protein (Tctp) and Rheb GTPase. Single knockdown of 14-3-3ɛ or 14-3-3ζ isoform does not show obvious defects in organ development but causes synergistic genetic interaction with Tctp and Rheb to impair tissue growth. 14-3-3 proteins physically interact with Tctp and Rheb. Knockdown of both 14-3-3 isoforms abolishes the binding between Tctp and Rheb, disrupting organ development. Depletion of 14-3-3s also reduces the level of phosphorylated S6 kinase, phosphorylated Thor/4E-BP and cyclin E (CycE). Growth defects from knockdown of 14-3-3 and Tctp are suppressed by CycE overexpression. This study suggests a novel mechanism of Tor regulation mediated by 14-3-3 interaction with Tctp and Rheb. | en |
dc.language.iso | en_US | en |
dc.publisher | Nature Publishing Group | en |
dc.relation.isversionof | doi:10.1038/ncomms11501 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859069/pdf/ | en |
dash.license | LAA | en_US |
dc.title | 14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature Communications | en |
dash.depositing.author | Hsu, Ya-Chieh | en_US |
dc.date.available | 2016-06-14T18:52:38Z | |
dc.identifier.doi | 10.1038/ncomms11501 | * |
dash.contributor.affiliated | Hsu, Ya-chieh | |