An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans
View/ Open
Author
Shen, Yu
Zhong, Connie
Qin, Yuqi
Kawano, Taizo
Wu, Min
Xu, Tianqi
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.7554/eLife.14197Metadata
Show full item recordCitation
Shen, Y., Q. Wen, H. Liu, C. Zhong, Y. Qin, G. Harris, T. Kawano, et al. 2016. “An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans.” eLife 5 (1): e14197. doi:10.7554/eLife.14197. http://dx.doi.org/10.7554/eLife.14197.Abstract
As a common neurotransmitter in the nervous system, γ-aminobutyric acid (GABA) modulates locomotory patterns in both vertebrates and invertebrates. However, the signaling mechanisms underlying the behavioral effects of GABAergic modulation are not completely understood. Here, we demonstrate that a GABAergic signal in C. elegans modulates the amplitude of undulatory head bending through extrasynaptic neurotransmission and conserved metabotropic receptors. We show that the GABAergic RME head motor neurons generate undulatory activity patterns that correlate with head bending and the activity of RME causally links with head bending amplitude. The undulatory activity of RME is regulated by a pair of cholinergic head motor neurons SMD, which facilitate head bending, and inhibits SMD to limit head bending. The extrasynaptic neurotransmission between SMD and RME provides a gain control system to set head bending amplitude to a value correlated with optimal efficiency of forward movement. DOI: http://dx.doi.org/10.7554/eLife.14197.001Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854516/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:27320436
Collections
- FAS Scholarly Articles [18256]
Contact administrator regarding this item (to report mistakes or request changes)