The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila

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The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila

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Title: The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila
Author: Ni, Lina; Klein, Mason; Svec, Kathryn V; Budelli, Gonzalo; Chang, Elaine C; Ferrer, Anggie J; Benton, Richard; Samuel, Aravinthan DT; Garrity, Paul A

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Citation: Ni, Lina, Mason Klein, Kathryn V Svec, Gonzalo Budelli, Elaine C Chang, Anggie J Ferrer, Richard Benton, Aravinthan DT Samuel, and Paul A Garrity. 2016. “The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila.” eLife 5 (1): e13254. doi:10.7554/eLife.13254. http://dx.doi.org/10.7554/eLife.13254.
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Abstract: Animals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood. The Dorsal Organ Cool Cells (DOCCs) of the Drosophila larva are a set of exceptionally thermosensitive neurons critical for larval cool avoidance. Here, we show that DOCC cool-sensing is mediated by Ionotropic Receptors (IRs), a family of sensory receptors widely studied in invertebrate chemical sensing. We find that two IRs, IR21a and IR25a, are required to mediate DOCC responses to cooling and are required for cool avoidance behavior. Furthermore, we find that ectopic expression of IR21a can confer cool-responsiveness in an Ir25a-dependent manner, suggesting an instructive role for IR21a in thermosensing. Together, these data show that IR family receptors can function together to mediate thermosensation of exquisite sensitivity. DOI: http://dx.doi.org/10.7554/eLife.13254.001
Published Version: doi:10.7554/eLife.13254
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851551/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27320438
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