The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila
View/ Open
Author
Ni, Lina
Svec, Kathryn V
Budelli, Gonzalo
Chang, Elaine C
Ferrer, Anggie J
Benton, Richard
Garrity, Paul A
Published Version
https://doi.org/10.7554/eLife.13254Metadata
Show full item recordCitation
Ni, Lina, Mason Klein, Kathryn V Svec, Gonzalo Budelli, Elaine C Chang, Anggie J Ferrer, Richard Benton, Aravinthan DT Samuel, and Paul A Garrity. 2016. “The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila.” eLife 5 (1): e13254. doi:10.7554/eLife.13254. http://dx.doi.org/10.7554/eLife.13254.Abstract
Animals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood. The Dorsal Organ Cool Cells (DOCCs) of the Drosophila larva are a set of exceptionally thermosensitive neurons critical for larval cool avoidance. Here, we show that DOCC cool-sensing is mediated by Ionotropic Receptors (IRs), a family of sensory receptors widely studied in invertebrate chemical sensing. We find that two IRs, IR21a and IR25a, are required to mediate DOCC responses to cooling and are required for cool avoidance behavior. Furthermore, we find that ectopic expression of IR21a can confer cool-responsiveness in an Ir25a-dependent manner, suggesting an instructive role for IR21a in thermosensing. Together, these data show that IR family receptors can function together to mediate thermosensation of exquisite sensitivity. DOI: http://dx.doi.org/10.7554/eLife.13254.001Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851551/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:27320438
Collections
- FAS Scholarly Articles [18256]
Contact administrator regarding this item (to report mistakes or request changes)