Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes

 
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Chan, Gail
White, Charles C.
Winn, Phoebe A.
Cimpean, Maria
Replogle, Joseph M.
Glick, Laura R.
Cuerdon, Nicole E.
Schneider, Julie A.
Bennett, David A.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/nn.4126
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Chan, G., C. C. White, P. A. Winn, M. Cimpean, J. M. Replogle, L. R. Glick, N. E. Cuerdon, et al. 2015. “Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes.” Nature neuroscience 18 (11): 1556-1558. doi:10.1038/nn.4126. http://dx.doi.org/10.1038/nn.4126.
Abstract
Here, we report results from a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. We find that the NME8 locus influences PTK2B and that the CD33 risk allele leads to greater TREM2 expression. Further, we observe (1) a decreased TREM1/TREM2 ratio with a TREM1 risk allele, (2) decreased TREM2 expression with CD33 suppression, and (3) elevated cortical TREM2 mRNA expression with amyloid pathology.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682915/pdf/
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:27320444

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