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dc.contributor.authorChan, Gailen_US
dc.contributor.authorWhite, Charles C.en_US
dc.contributor.authorWinn, Phoebe A.en_US
dc.contributor.authorCimpean, Mariaen_US
dc.contributor.authorReplogle, Joseph M.en_US
dc.contributor.authorGlick, Laura R.en_US
dc.contributor.authorCuerdon, Nicole E.en_US
dc.contributor.authorRyan, Katie J.en_US
dc.contributor.authorJohnson, Keith A.en_US
dc.contributor.authorSchneider, Julie A.en_US
dc.contributor.authorBennett, David A.en_US
dc.contributor.authorChibnik, Lori B.en_US
dc.contributor.authorSperling, Reisa A.en_US
dc.contributor.authorBradshaw, Elizabeth M.en_US
dc.contributor.authorDe Jager, Philip L.en_US
dc.date.accessioned2016-06-14T18:53:46Z
dc.date.issued2015en_US
dc.identifier.citationChan, G., C. C. White, P. A. Winn, M. Cimpean, J. M. Replogle, L. R. Glick, N. E. Cuerdon, et al. 2015. “Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes.” Nature neuroscience 18 (11): 1556-1558. doi:10.1038/nn.4126. http://dx.doi.org/10.1038/nn.4126.en
dc.identifier.issn1097-6256en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27320444
dc.description.abstractHere, we report results from a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. We find that the NME8 locus influences PTK2B and that the CD33 risk allele leads to greater TREM2 expression. Further, we observe (1) a decreased TREM1/TREM2 ratio with a TREM1 risk allele, (2) decreased TREM2 expression with CD33 suppression, and (3) elevated cortical TREM2 mRNA expression with amyloid pathology.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nn.4126en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682915/pdf/en
dash.licenseLAAen_US
dc.titleModulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature neuroscienceen
dash.depositing.authorRyan, Katie J.en_US
dc.date.available2016-06-14T18:53:46Z
dc.identifier.doi10.1038/nn.4126*
dash.authorsorderedfalse
dash.contributor.affiliatedBradshaw, Elizabeth M.
dash.contributor.affiliatedRyan, Katie J.
dash.contributor.affiliatedJohnson, Keith
dash.contributor.affiliatedChibnik, Lori
dash.contributor.affiliatedSperling, Reisa
dash.contributor.affiliatedDe Jager, Philip


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