Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder
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Baek, Ji Hyun
Kim, Hee-Jin
Heo, Jung-Yoon
Jeon, Hong Jin
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https://doi.org/10.4306/pi.2016.13.3.321Metadata
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Baek, Ji Hyun, Hee-Jin Kim, Maurizio Fava, David Mischoulon, George I Papakostas, Andrew Nierenberg, Jung-Yoon Heo, and Hong Jin Jeon. 2016. “Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder.” Psychiatry Investigation 13 (3): 321-326. doi:10.4306/pi.2016.13.3.321. http://dx.doi.org/10.4306/pi.2016.13.3.321.Abstract
Objective: Anxious depression has a distinct neurobiology, clinical course and treatment response from non-anxious depression. Role of inflammation in anxious depression has not been examined. As an exploratory study to characterize the role of inflammation on a development of anxious depression, we aimed to determine the relationship between white blood cell (WBC) subset counts and anxiety in individuals with major depressive disorder (MDD). Methods: A total of 709 patients who were newly diagnosed with MDD were recruited. Anxiety levels of participants were evaluated using the Anxiety/ Somatization subitem of the Hamilton Depression Rating Scale. The association between WBC subset fraction and anxiety was evaluated. Results: Basophil and eosinophil sub-fractions showed significant negative correlations with HAM-D anxiety/somatization factor scores (basophils: r=-0.092, p=0.014 and eosinophils: r=-0.075, p=0.046). When an anxiety score (a sum of somatic and psychic anxiety) was entered as a dependent variable, only basophils showed significant negative association with the anxiety scores after adjusting for all other WBC subset counts and demographic factors (t=-2.57, p=0.010). Conclusion: This study showed that anxious depression had a decreased basophil subfraction, which might be associated with involvement of inflammation in development of anxious depression.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878967/pdf/Terms of Use
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