ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

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Author
Johnatty, Sharon E.
Beesley, Jonathan
Gao, Bo
Chen, Xiaoqing
Lu, Yi
Law, Matthew H.
Henderson, Michelle J.
Russell, Amanda J.
Hedditch, Ellen L.
Emmanuel, Catherine
Fereday, Sian
Webb, Penelope M.
Goode, Ellen L.
Vierkant, Robert A.
Fridley, Brooke L.
Cunningham, Julie M
Fasching, Peter A.
Beckmann, Matthias W.
Ekici, Arif B.
Hogdall, Estrid
Kjaer, Susanne K.
Jensen, Allan
Hogdall, Claus
Brown, Robert
Paul, Jim
Lambrechts, Sandrina
Despierre, Evelyn
Vergote, Ignace
Lester, Jenny
Karlan, Beth Y.
Heitz, Florian
du Bois, Andreas
Harter, Philipp
Schwaab, Ira
Bean, Yukie
Pejovic, Tanja
Levine, Douglas A.
Goodman, Marc T.
Camey, Michael E.
Thompson, Pamela J.
Lurie, Galina
Shildkraut, Joellen
Berchuck, Andrew
Norris, Murray D.
Haber, Michelle
MacGregor, Stuart
deFazio, Anna
Chenevix-Trench, Georgia
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1016/j.ygyno.2013.07.107Metadata
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Johnatty, Sharon E., Jonathan Beesley, Bo Gao, Xiaoqing Chen, Yi Lu, Matthew H. Law, Michelle J. Henderson, et al. 2013. “ABCB1 (MDR1) Polymorphisms and Ovarian Cancer Progression and Survival: A Comprehensive Analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas.” Gynecologic Oncology 131 (1) (October): 8–14. doi:10.1016/j.ygyno.2013.07.107.Abstract
ObjectiveABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC).
Methods
The best candidates from fine-mapping analysis of 21 ABCB1 SNPs tagging C1236T (rs1128503), G2677T/A (rs2032582), and C3435T (rs1045642) were analysed in 4,616 European invasive EOC patients from thirteen Ovarian Cancer Association Consortium (OCAC) studies and The Cancer Genome Atlas (TCGA). Additionally we analysed 1,562 imputed SNPs around ABCB1 in patients receiving cytoreductive surgery and either ‘standard’ first-line paclitaxel-carboplatin chemotherapy (n=1,158) or any first-line chemotherapy regimen (n=2,867). We also evaluated ABCB1 expression in primary tumours from 143 EOC patients.
Result
Fine-mapping revealed that rs1128503, rs2032582, and rs1045642 were the best candidates in optimally debulked patients. However, we observed no significant association between any SNP and either progression-free survival or overall survival in analysis of data from 14 studies. There was a marginal association between rs1128503 and overall survival in patients with nil residual disease (HR 0.88, 95% CI 0.77-1.01; p=0.07). In contrast, ABCB1 expression in the primary tumour may confer worse prognosis in patients with sub-optimally debulked tumours.
Conclusion
Our study represents the largest analysis of ABCB1 SNPs and EOC progression and survival to date, but has not identified additional signals, or validated reported associations with progression-free survival for rs1128503, rs2032582, and rs1045642. However, we cannot rule out the possibility of a subtle effect of rs1128503, or other SNPs linked to it, on overall survival.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795832/Terms of Use
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