ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

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ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

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Title: ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium
Author: Poole, Elizabeth M.; Gates, Margaret A.; High, Brigit A.; Chanock, Stephen J.; Cramer, Daniel William; Cunningham, Julie M.; Fridley, Brooke L.; Gayther, Simon A.; Goode, Ellen L.; Iversen, Edwin S.; Lissowska, Jolanta; Weber, Rachel T. Palmieri; Pharoah, Paul D. P.; Phelan, Catherine M.; Ramus, Susan J.; Schildkraut, Joellen M.; Sutphen, Rebecca; Tsai, Ya-Yu; Tyrer, Jonathan; Vierkant, Robert A.; Wentzensen, Nicolas; Yang, Hannah P.; Terry, Kathryn Lynne; Tworoger, Shelley Slate

Note: Order does not necessarily reflect citation order of authors.

Citation: Poole, Elizabeth M., Margaret A. Gates, Brigit A. High, Stephen J. Chanock, Daniel W. Cramer, Julie M. Cunningham, Brooke L. Fridley, et al. 2012. “ABO Blood Group and Risk of Epithelial Ovarian Cancer Within the Ovarian Cancer Association Consortium.” Cancer Causes Control 23 (11) (September 8): 1805–1810. doi:10.1007/s10552-012-0059-y. http://dx.doi.org/10.1007/s10552-012-0059-y.
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Abstract: Purpose

Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results.

Methods

In 8 studies participating in the Ovarian Cancer Association Consortium (OCAC), we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis.

Results

Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95% CI: 1.01–1.18; p=0.03). In diplotype analysis, the AO, but not the AA diplotype was associated with increased risk (AO: OR: 1.11; 95% CI: 1.01–1.22; p=0.03; AA: OR: 1.03; 95% CI: 0.87–1.21; p=0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes.

Conclusion

Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.
Published Version: doi:10.1007/s10552-012-0059-y
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474344/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27332426
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