Serum and follicular fluid concentrations of polybrominated diphenyl ethers and in-vitro fertilization outcome

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Serum and follicular fluid concentrations of polybrominated diphenyl ethers and in-vitro fertilization outcome

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Title: Serum and follicular fluid concentrations of polybrominated diphenyl ethers and in-vitro fertilization outcome
Author: Johnson, Paula I.; Altshul, Larisa M.; Cramer, Daniel William; Missmer, Stacey Ann; Hauser, Russ B.; Meeker, John D.

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Citation: Johnson, Paula I., Larisa Altshul, Daniel W. Cramer, Stacey A. Missmer, Russ Hauser, and John D. Meeker. 2012. “Serum and Follicular Fluid Concentrations of Polybrominated Diphenyl Ethers and in-Vitro Fertilization Outcome.” Environment International 45 (September): 9–14. doi:10.1016/j.envint.2012.04.004.
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Abstract: There is evidence of endocrine disruption and reproductive effects in animals following exposure to certain PBDEs, but human studies are limited. The goal of this study was to investigate the use of serum and follicular fluid as biomarkers of exposure to PBDEs and to explore whether a relationship between PBDE exposure and early pregnancy loss exists. We measured 8 PBDE congeners in archived serum and ovarian follicular fluid samples from 65 women undergoing in-vitro fertilization (IVF). Logistic regression models were used to predict the odds of failed embryo implantation associated with higher levels of PBDEs among the women in the study. There were moderate Kendall’s Tau-beta correlations between serum and follicular fluid concentrations of BDE 28, 47, 100 and 154 (Tβ =0.29–0.38, all p-values<0.005), but BDE 99 and 153 were not correlated between the two matrices (Tβ<0.2, p-values>0.05). Women with detectable concentrations of BDE 153 (39% had detectable levels) in follicular fluid had elevated odds of failed implantation compared with women who had non-detectable concentrations (adjusted OR=10.0; 95%CI: 1.9 to 52; p=0.006; adjusted by age and body mass index). These findings suggest that exposure to BDE 153 may be associated with failed embryo implantation. Due to our observation of only moderate correlations between matrices, serum PBDE concentrations may not be a good indicator of follicular fluid concentrations when studying early pregnancy endpoints in women undergoing IVF.
Published Version: doi:10.1016/j.envint.2012.04.004
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366013/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27332625
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