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dc.contributor.authorMeeker, John D.
dc.contributor.authorMaity, Arnab
dc.contributor.authorMissmer, Stacey Ann
dc.contributor.authorWilliams, Paige L.
dc.contributor.authorMahalingaiah, Shruthi
dc.contributor.authorEhrlich, Shelley
dc.contributor.authorBerry, Katharine F.
dc.contributor.authorAltshul, Larisa M.
dc.contributor.authorPerry, Melissa
dc.contributor.authorCramer, Daniel William
dc.contributor.authorHauser, Russ B.
dc.date.accessioned2016-06-16T15:39:58Z
dc.date.issued2011
dc.identifier.citationMeeker, John D., Arnab Maity, Stacey A. Missmer, Paige L. Williams, Shruthi Mahalingaiah, Shelley Ehrlich, Katharine F. Berry, et al. 2011. “Serum Concentrations of Polychlorinated Biphenyls in Relation to in Vitro Fertilization Outcomes.” Environmental Health Perspectives 119 (7) (February 24): 1010–1016. doi:10.1289/ehp.1002922.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27332761
dc.description.abstractBackground: Human exposure to polychlorinated biphenyls (PCBs) remains widespread. PCBs have been associated with adverse reproductive health outcomes including reduced fecundability and increased risk of pregnancy loss, although the human data remain largely inconclusive. Objective: Our goal was to explore the relationship between serum PCB concentrations and early pregnancy loss among a large cohort of women undergoing in vitro fertilization (IVF) between 1994 and 2003. Methods: Concentrations of 57 PCB congeners were measured in serum samples collected during 827 IVF/intracytoplasmic sperm injection cycles from 765 women. Joint statistical models that accommodate multiple outcomes and multiple cycles per woman were used to assess the relationship between serum PCB quartiles and implantation failure, chemical pregnancies (human chorionic gonadotropin level > 5.0 mIU/mL) that did not result in clinical pregnancy, or spontaneous abortion, while also adjusting for confounders. Results: PCB-153 was the congener present in the highest concentration (median, 46.2 ng/g lipid). Increasing quartiles of PCB-153 and the sum of all measured PCB congeners (ΣPCBs) were associated with significantly elevated dose-dependent odds of failed implantation. Adjusted odds ratios (95% confidence interval) for highest versus lowest quartile were 2.0 (1.2–3.4) for PCB-153 and 1.7 (1.0–2.9) for ΣPCBs. There were suggestive trends for increased odds of implantation failure for PCB-118 and cytochrome P450–inducing congeners (p-values for trend = 0.06). No statistically significant associations between PCBs and chemical pregnancy or spontaneous abortion were found. Conclusions: Serum PCB concentrations at levels similar to the U.S. general population were associated with failed implantation among women undergoing IVF. These findings may help explain previous reports of reduced fecundability among women exposed to PCBs.en_US
dc.language.isoen_USen_US
dc.publisherEnvironmental Health Perspectivesen_US
dc.relation.isversionofdoi:10.1289/ehp.1002922en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222973/en_US
dash.licenseLAA
dc.subjectenvironmenten_US
dc.subjectepidemiologyen_US
dc.subjectfemaleen_US
dc.subjectorganochlorineen_US
dc.subjectreproductionen_US
dc.titleSerum Concentrations of Polychlorinated Biphenyls in Relation to in Vitro Fertilization Outcomesen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalEnviron Health Perspecten_US
dash.depositing.authorCramer, Daniel William
dc.date.available2016-06-16T15:39:58Z
dc.identifier.doi10.1289/ehp.1002922*
dash.authorsorderedfalse
dash.contributor.affiliatedPerry, Melissa J.
dash.contributor.affiliatedMahalingaiah, Shruthi
dash.contributor.affiliatedHauser, Russ
dash.contributor.affiliatedWilliams, Paige
dash.contributor.affiliatedAltshul, Larisa
dash.contributor.affiliatedCramer, Daniel
dash.contributor.affiliatedMissmer, Stacey


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