A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

 
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Goode, Ellen L
Chenevix-Trench, Georgia
Song, Honglin
Ramus, Susan J
Notaridou, Maria
Lawrenson, Kate
Widschwendter, Martin
Vierkant, Robert A
Larson, Melissa C
Kjaer, Susanne K
Berchuck, Andrew
Schildkraut, Joellen
Tomlinson, Ian
Kiemeney, Lambertus A
Cook, Linda S
Gronwald, Jacek
Garcia-Closas, Montserrat
Gore, Martin E
Campbell, Ian
Whittemore, Alice S
Sutphen, Rebecca
Phelan, Catherine
Anton-Culver, Hoda
Pearce, Celeste Leigh
Lambrechts, Diether
Rossing, Mary Anne
Chang-Claude, Jenny
Moysich, Kirsten B
Goodman, Marc T
Dörk, Thilo
Nevanlinna, Heli
Ness, Roberta B
Rafnar, Thorunn
Hogdall, Claus
Hogdall, Estrid
Fridley, Brooke L
Cunningham, Julie M
Sieh, Weiva
McGuire, Valerie
Godwin, Andrew K
Hernandez, Dena
Levine, Douglas
Lu, Karen
Iversen, Edwin S
Palmieri, Rachel T
Houlston, Richard
van Altena, Anne M
Aben, Katja K H
Massuger, Leon F A G
Brooks-Wilson, Angela
Kelemen, Linda E
Le, Nhu D
Jakubowska, Anna
Lubinski, Jan
Medrek, Krzysztof
Stafford, Anne
Easton, Douglas F
Tyrer, Jonathan
Bolton, Kelly L
Harrington, Patricia
Eccles, Diana
Chen, Ann
Molina, Ashley N
Davila, Barbara N
Arango, Hector
Tsai, Ya-Yu
Chen, Zhihua
Risch, Harvey A
McLaughlin, John
Narod, Steven A
Ziogas, Argyrios
Brewster, Wendy
Gentry-Maharaj, Aleksandra
Menon, Usha
Wu, Anna H
Stram, Daniel O
Pike, Malcolm C
Beesley, Jonathan
Webb, Penelope M
Chen, Xiaoqing
Ekici, Arif B
Thiel, Falk C
Beckmann, Matthias W
Yang, Hannah
Wentzensen, Nicolas
Lissowska, Jolanta
Fasching, Peter A
Despierre, Evelyn
Amant, Frederic
Vergote, Ignace
Doherty, Jennifer
Hein, Rebecca
Wang-Gohrke, Shan
Lurie, Galina
Carney, Michael E
Thompson, Pamela J
Runnebaum, Ingo
Hillemanns, Peter
Dürst, Matthias
Antonenkova, Natalia
Bogdanova, Natalia
Leminen, Arto
Butzow, Ralf
Heikkinen, Tuomas
Stefansson, Kari
Sulem, Patrick
Besenbacher, Sören
Sellers, Thomas A
Gayther, Simon A
Pharoah, Paul D P
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ng.668
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Goode, Ellen L, Georgia Chenevix-Trench, Honglin Song, Susan J Ramus, Maria Notaridou, Kate Lawrenson, Martin Widschwendter, et al. 2010. “A Genome-Wide Association Study Identifies Susceptibility Loci for Ovarian Cancer at 2q31 and 8q24.” Nat Genet 42 (10) (September 19): 874–879. doi:10.1038/ng.668.
Abstract
Ovarian cancer (OC) accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance OC susceptibility genes, we conducted a genome-wide association study (GWAS) of 507,094 SNPs in 1,768 cases and 2,354 controls, with follow-up of 21,955 SNPs in 4,162 cases and 4,810 controls, leading to the identification of a confirmed susceptibility locus at 9p22 (BNC2)1. Here, we report on nine additional candidate loci (p≤10-4), identified after stratifying cases by histology, genotyped in an additional 4,353 cases and 6,021 controls. Two novel susceptibility loci with p≤5×10-8 were confirmed (8q24, p=8.0×10-15 and 2q31, p=3.8×10-14); two additional loci were also identified that approached genome-wide significance (3q25, p=7.1×10-8 and 17q21, p=1.4×10-7). The associations with serous OC were generally stronger than other subtypes. Analysis of HOXD1, MYC, TiPARP, and SKAP1 at these loci, and BNC2 at 9p22, supports a functional role for these genes in OC development.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020231/
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:27332764

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