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dc.contributor.authorGates, Margaret A.
dc.contributor.authorWolpin, Brian M.
dc.contributor.authorCramer, Daniel William
dc.contributor.authorHankinson, Susan Elizabeth
dc.contributor.authorTworoger, Shelley Slate
dc.date.accessioned2016-06-16T15:53:25Z
dc.date.issued2010
dc.identifier.citationGates, Margaret A., Brian M. Wolpin, Daniel W. Cramer, Susan E. Hankinson, and Shelley S. Tworoger. 2010. “ABO Blood Group and Incidence of Epithelial Ovarian Cancer.” Int. J. Cancer 128 (2) (March 22): 482–486. doi:10.1002/ijc.25339.en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27332767
dc.description.abstractPrevious studies have observed an association between ABO blood group and risk of certain malignancies, including ovarian cancer; however, no prospective studies of the association with ovarian cancer risk are available. Using data from 49,153 women in the Nurses’ Health Study, we examined the association between ABO blood group and incidence of epithelial ovarian cancer. Study participants reported their blood type and Rh factor in 1996, and 234 women were diagnosed with incident ovarian cancer during 10 years of follow-up. We used Cox proportional hazards regression to model the incidence rate ratios (RR) and 95% confidence intervals (CI) of ovarian cancer for each blood group category. Compared to women with blood group O, women with blood group AB or B had a non-significant 38% increase in ovarian cancer incidence (95% CI=0.88–2.16 for blood group AB and 0.96–1.99 for blood group B), while blood group A was not associated with risk (RR=0.95, 95% CI=0.70–1.30). Combining blood groups AB and B, we observed a statistically significant positive association with presence versus absence of the B antigen overall (RR=1.41, 95% CI=1.06–1.88) and for the serous invasive subtype (RR=1.53, 95% CI=1.08–2.17). In this large, prospective cohort of women, presence of the B antigen was positively associated with ovarian cancer incidence, while blood group A was not associated with risk. Additional studies are needed to confirm this association and to explore the mechanisms through which blood group may influence ovarian cancer risk.en_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionofdoi:10.1002/ijc.25339en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946962/en_US
dash.licenseLAA
dc.subjectOvarian Neoplasmsen_US
dc.subjectABO Blood Groupen_US
dc.subjectCohort Studiesen_US
dc.subjectProspective Studiesen_US
dc.titleABO blood group and incidence of epithelial ovarian canceren_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalInternational Journal of Canceren_US
dash.depositing.authorCramer, Daniel William
dc.date.available2016-06-16T15:53:25Z
dc.identifier.doi10.1002/ijc.25339*
dash.contributor.affiliatedHankinson, Susan
dash.contributor.affiliatedTworoger, Shelley
dash.contributor.affiliatedCramer, Daniel


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