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dc.contributor.authorKotsopoulos, Joanne
dc.contributor.authorVitonis, Allison F.
dc.contributor.authorTerry, Kathryn Lynne
dc.contributor.authorDe Vivo, Immaculata
dc.contributor.authorCramer, Daniel William
dc.contributor.authorHankinson, Susan Elizabeth
dc.contributor.authorTworoger, Shelley Slate
dc.date.accessioned2016-06-17T16:32:51Z
dc.date.issued2008
dc.identifier.citationKotsopoulos, Joanne, Allison F. Vitonis, Kathryn L. Terry, Immaculata De Vivo, Daniel W. Cramer, Susan E. Hankinson, and Shelley S. Tworoger. 2008. “Coffee Intake, Variants in Genes Involved in Caffeine Metabolism, and the Risk of Epithelial Ovarian Cancer.” Cancer Causes Control 20 (3) (October 21): 335–344. doi:10.1007/s10552-008-9247-1.en_US
dc.identifier.issn0957-5243en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27336516
dc.description.abstractWe evaluated whether genetic variability, as well as menopausal status, modify the association between coffee intake and risk of ovarian cancer. Risk factor information and biologic specimens from three large epidemiological studies, the Nurses’ Health Study (NHS), NHSII, and the New England based Case-Control study of ovarian cancer (NECC) were pooled resulting in 1354 ovarian cancer cases and 1851 controls for analysis. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using conditional (NHS/NHSII) and unconditional (NECC) logistic regression. Coffee consumption was not associated with risk overall (OR = 0.99; 95% CI 0.77–1.28); however, there was a suggested increased risk of ovarian cancer among premenopausal women in the NECC only and an inverse association among postmenopausal women. Carrying one or both of the variant CYP19013 A or CYP19027 G alleles was associated with an 18% increased (P for trend = 0.02) and 15% decreased (P for trend = 0.05) risk of ovarian cancer, respectively. Variation in CYP1A1, CYP1A2, or CYP2A6, did not explain the inconsistent reports of coffee intake and risk. Furthermore, we did not observe any clear gene-environment interactions between caffeine metabolizing genes and ovarian cancer. Future studies evaluating mechanisms by which coffee mediates this relationship are warranted.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science + Business Mediaen_US
dc.relation.isversionofdoi:10.1007/s10552-008-9247-1en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692932/en_US
dash.licenseLAA
dc.subjectovarian canceren_US
dc.subjectcoffeeen_US
dc.subjectCYP1A1en_US
dc.subjectCYP1A2en_US
dc.subjectCYP2A6en_US
dc.subjectCYP19en_US
dc.titleCoffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian canceren_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalCancer Causes & Controlen_US
dash.depositing.authorCramer, Daniel William
dc.date.available2016-06-17T16:32:51Z
dc.identifier.doi10.1007/s10552-008-9247-1*
dash.contributor.affiliatedTerry, Kathryn
dash.contributor.affiliatedTworoger, Shelley
dash.contributor.affiliatedCramer, Daniel
dash.contributor.affiliatedDe Vivo, Immaculata
dash.contributor.affiliatedHankinson, Susan


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