Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer

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Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer

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dc.contributor.author Kotsopoulos, Joanne
dc.contributor.author Vitonis, Allison F.
dc.contributor.author Terry, Kathryn Lynne
dc.contributor.author De Vivo, Immaculata
dc.contributor.author Cramer, Daniel William
dc.contributor.author Hankinson, Susan Elizabeth
dc.contributor.author Tworoger, Shelley Slate
dc.date.accessioned 2016-06-17T16:32:51Z
dc.date.issued 2008
dc.identifier.citation Kotsopoulos, Joanne, Allison F. Vitonis, Kathryn L. Terry, Immaculata De Vivo, Daniel W. Cramer, Susan E. Hankinson, and Shelley S. Tworoger. 2008. “Coffee Intake, Variants in Genes Involved in Caffeine Metabolism, and the Risk of Epithelial Ovarian Cancer.” Cancer Causes Control 20 (3) (October 21): 335–344. doi:10.1007/s10552-008-9247-1. en_US
dc.identifier.issn 0957-5243 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:27336516
dc.description.abstract We evaluated whether genetic variability, as well as menopausal status, modify the association between coffee intake and risk of ovarian cancer. Risk factor information and biologic specimens from three large epidemiological studies, the Nurses’ Health Study (NHS), NHSII, and the New England based Case-Control study of ovarian cancer (NECC) were pooled resulting in 1354 ovarian cancer cases and 1851 controls for analysis. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using conditional (NHS/NHSII) and unconditional (NECC) logistic regression. Coffee consumption was not associated with risk overall (OR = 0.99; 95% CI 0.77–1.28); however, there was a suggested increased risk of ovarian cancer among premenopausal women in the NECC only and an inverse association among postmenopausal women. Carrying one or both of the variant CYP19013 A or CYP19027 G alleles was associated with an 18% increased (P for trend = 0.02) and 15% decreased (P for trend = 0.05) risk of ovarian cancer, respectively. Variation in CYP1A1, CYP1A2, or CYP2A6, did not explain the inconsistent reports of coffee intake and risk. Furthermore, we did not observe any clear gene-environment interactions between caffeine metabolizing genes and ovarian cancer. Future studies evaluating mechanisms by which coffee mediates this relationship are warranted. en_US
dc.language.iso en_US en_US
dc.publisher Springer Science + Business Media en_US
dc.relation.isversionof doi:10.1007/s10552-008-9247-1 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692932/ en_US
dash.license LAA
dc.subject ovarian cancer en_US
dc.subject coffee en_US
dc.subject CYP1A1 en_US
dc.subject CYP1A2 en_US
dc.subject CYP2A6 en_US
dc.subject CYP19 en_US
dc.title Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer en_US
dc.type Journal Article en_US
dc.description.version Accepted Manuscript en_US
dc.relation.journal Cancer Causes & Control en_US
dash.depositing.author Cramer, Daniel William
dc.date.available 2016-06-17T16:32:51Z

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